Evidence item

An independent Nature study reports m1Psi-associated +1 frameshifting and shows synonymous targeting of slippery sequences reduces frameshifted products. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 18012

Source: N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting · locator {} · excerpt hash sha256:157a4799b5bf3553dc8b3740ade4e1264d28686c09133f5901212de983e2969c

Exact excerpt

Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro ... The +1 ribosome frameshifting observed is probably a consequence of N1-methylpseudouridine-induced ribosome stalling ... synonymous targeting of such slippery sequences provides an effective strategy to reduce the production of frameshifted products.

Linked claims

Claim	Direction	Relevance	Steps	Counted
67d283bd	SUPPORT	STRONG	0	yes

Audits

None.