Evidence item

The trial report describes 68,141 procedures, reduced postoperative opioid exposure, unchanged patient-reported pain interference and physical function, and no worsening of reported safety outcomes. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 19206

Source: September 28, 2026: NOHARM Trial Finds Reduction in Postoperative Opioid Exposure Without Changes in Patient-Reported Outcomes · locator {} · excerpt hash sha256:cc5bcb8038b425d7a17ef046646fbad60160922707a88fb9e8e3c72c8e7e1145

Exact excerpt

In the NOHARM trial, a strategy to promote nondrug pain management after surgery reduced exposure to opioids without worsening pain interference, physical function, and other patient-reported outcomes. ... A total of 68,141 surgical procedures were included in the analysis ... The researchers found no change in patient-reported pain interference and physical function. However, the intervention reduced exposure to opioids after surgery ... These reductions ... were achieved without worsening patient-reported outcomes, opioid-related adverse events, or other safety outcomes.

Linked claims

Claim	Direction	Relevance	Steps	Counted
6442452b	SUPPORT	DIRECT	0	yes

Audits

None.