Evidence item

Independent oncology coverage confirms the control and survival differences and reports no significant overall adverse-event difference. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 19064

Source: Multi-fraction radiation significantly improves local control for large brain metastases · locator {} · excerpt hash sha256:5b901633d62e5073181c24c96b69cf6c38dd51d9c03b8b1c15df15d011cfefc8

After median follow-up of 48 months, the multi-fraction arm had significantly improved 1-year local control at the resected cavity (87% vs. 81%; P = .046) ... The multi-fraction arm also had significantly improved median OS (28.6 months vs. 20.2 months; HR = 0.66; 95% CI, 0.46-0.94). ... Adverse events did not significantly differ either.