Evidence item

The Nature passage directly lists the demonstrated applications and primary-human-cell scope. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 14149

Source: Prime assembly enables RNA-programmable, site-specific integration of medium-to-large DNA sequences in human cells · locator {} · excerpt hash sha256:2c5d6c4080858a6e958782871915336bd28aba708888dc7cae6c70fee8f97c0b

We applied prime assembly to perform targeted exon recoding, transgene integration and megabase-scale rearrangements, including at therapeutically relevant loci in primary human cells.