Evidence item

The Swedish cohort found pathogenic germline alterations in 9 of 181 children, with tailored surveillance for eight and treatment modifications for four. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 17699

Source: Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort · locator {} · excerpt hash sha256:ab3e593a13120ef09e98403202538937751312c2a34545a56d36eca8aefd5cd6

In the Swedish nationwide, population-based, prospective, multi-center study of 181 patients, this integrated approach identifies pathogenic germline alterations in nine patients (5%; 3.3% leukemia predisposition, 1.7% solid tumor predisposition), six of whom are previously unrecognized, prompting tailored surveillance in eight and treatment modification in four.