Evidence item

The passage reports no significant treatment-by-metabolic-syndrome interaction for analyses and safety, with hypotension numerically more frequent in the highest tertile. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 24921

Source: Metabolic syndrome severity and the effects of intensive blood pressure lowering: Results from the STEP randomized trial · locator {} · excerpt hash sha256:7f4936b1cfbd2c0d51e919437243723debeb7fc37d40419847561da5ee57e506

Exact excerpt

During a median follow-up of 3.32 years, intensive SBP lowering reduced the risk of the primary outcome compared with standard treatment. The absolute incidence of the primary outcome and major adverse cardiac events was highest in the highest MetS tertile. Across MetS tertiles, event rates were lower in the intensive-treatment group, with the largest reduction in the middle tertile for the primary outcome (Q2: HR, 0.66; 95% CI, 0.44–0.99). No significant treatment-by-MetS interaction was observed in tertile-based or spline analyses. For safety outcomes, no significant treatment-by-MetS tertile interaction was observed, although hypotension was numerically more frequent with intensive treatment among participants in the highest MetS tertile.

Linked claims

Claim	Direction	Relevance	Steps	Counted
288994bc	SUPPORT	DIRECT	0	yes

Audits

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