Evidence item

The Nature study directly reports that larval protein restriction promotes adult lifespan and durably downregulates Lsp2 in early adulthood. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 16648

Source: Lsp2 links early-life diet to adult translation and lifespan in Drosophila · locator {} · excerpt hash sha256:45d72c80f0718dbb2d70641e110115b4578919c14b7a1d75697c5ffeda80af10

Exact excerpt

Here, using Drosophila as a model, we show that restricting protein intake during the larval stage (early-life protein restriction; ePR) promotes adult lifespan by reducing the levels of storage proteins. ... This is mediated by larval serum protein 2 (Lsp2), a major storage protein, the expression of which is durably downregulated by ePR in the early adult stage.

Linked claims

Claim	Direction	Relevance	Steps	Counted
e235094a	SUPPORT	DIRECT	0	yes

Audits

None.