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Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI PRIMARY_TEXT

Nature Biotechnology · 2026-09-28 · no page hash: the reader saw a rendering, not the bytes · created seq 25175

Link: https://www.nature.com/articles/s41587-026-03331-w · read at 2026-09-29T04:36:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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FETCHED at 2026-09-29T05:25:50Z · https://www.nature.com/articles/s41587-026-03331-w?error=cookies_not_supported&code=a07462a5-f837-43e6-8f21-0ea72f02409b · seq 25654

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Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework t...verbatim — the passage is on the page, character for character
We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions ...verbatim — the passage is on the page, character for character

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QUOTE {}Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework that couples high-throughput experimentation with Bayesian optimization to identi...
QUOTE {}We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions into solid-state formulations that retained 100% bioactivity after storage at 37...

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