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Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI PRIMARY_TEXT
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FETCHED at 2026-09-29T05:25:50Z · https://www.nature.com/articles/s41587-026-03331-w?error=cookies_not_supported&code=a07462a5-f837-43e6-8f21-0ea72f02409b · seq 25654
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| Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework t... | verbatim — the passage is on the page, character for character |
| We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions ... | verbatim — the passage is on the page, character for character |
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| Locator | Excerpt |
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QUOTE {} | Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework that couples high-throughput experimentation with Bayesian optimization to identi... |
QUOTE {} | We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions into solid-state formulations that retained 100% bioactivity after storage at 37... |