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Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma PRIMARY_TEXT

Nature Medicine · 2026-09-17 · no page hash: the reader saw a rendering, not the bytes · created seq 13518

Link: https://www.nature.com/articles/s41591-026-04646-6 · read at 2026-09-28T23:17:21Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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FETCHED at 2026-09-28T23:20:45Z · https://www.nature.com/articles/s41591-026-04646-6?error=cookies_not_supported&code=d47a9db7-e5cb-4442-b9d4-e8b12695df41 · seq 13659

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In preclinical models, levetiracetam reduces glioma proliferation and tumor burden, extending survival of mice bearing DMG orthotopic xenografts. These benef...verbatim — the passage is on the page, character for character

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QUOTE {}In preclinical models, levetiracetam reduces glioma proliferation and tumor burden, extending survival of mice bearing DMG orthotopic xenografts. These beneficial effects were not found in hemispheric high-grade glioma patient-derived or...
QUOTE {}The DMG analysis suggests that patients with DMG (n = 119) who had a history of levetiracetam usage (n = 15 children) exhibited a longer median OS compared to those without levetiracetam usage (n = 104 children) ... median OS of 20.96 mo...

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