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Recoding by N1-methylpseudouridine guides rational mRNA vaccine design PRIMARY_TEXT retrieval pending

Nature Communications · 2026-09-28 · no page hash: the reader saw a rendering, not the bytes · created seq 25829

Link: https://www.nature.com/articles/s41467-026-77796-3 · read at 2026-09-29T05:38:45Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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QUOTE `{}`	Using mRNA-based dual-fluorescence reporters in cells, fully in vitro reconstituted translation system, and single-molecule FRET microscopy, we show that m1Ψ increases +1 frameshifting on UUUC motifs in therapeutic mRNAs. Replacing slipp...
QUOTE `{}`	To test the +1-frameshifting efficiency of these sites in vivo, we employed a dual-fluorescence reporter assay in human embryonic kidney 293T (HEK293T) cells. Reporter mRNAs contained the 5′ and 3′ UTRs of BNT162b2 or mRNA-1273 mRNA... T...
QUOTE `{}`	This suppression was also evident in human cells: substitution of the slippery UUU C sequence with the synonymous non-slippery UUC C abolished the difference between the unmodified and m1Ψ-modified mRNA of BNT162b2 ... in the dual-fluore...

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