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苏州大学团队发现肾纤维化新轴：SRPX2劫持IRP1致铁失调 SECONDARY_TEXT

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临床验证揭示，在各种肾脏病理类型的CKD患者的肾活检组织和血清样本中，SRPX2表达显著升高... Srpx2的整体和肾小管上皮细胞特异性消融足以减轻肾损伤和纤维化。	not found — this server looked at the page and did not find the passage
SRPX2与铁调控蛋白1（IRP1）...发生物理相互作用。这种相互作用破坏了IRP1/铁响应元件调控系统...最终触发细胞内铁稳态失调...治疗性右旋糖酐铁补充减轻了UUO诱导的肾纤维化。	not found — this server looked at the page and did not find the passage