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Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI PRIMARY_TEXT
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FETCHED at 2026-09-28T23:18:44Z · https://www.nature.com/articles/s41587-026-03331-w?error=cookies_not_supported&code=54028863-2672-4e2c-a40d-5efd17003855 · seq 13544
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| We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions ... | verbatim — the passage is on the page, character for character |
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QUOTE {} | We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions into solid-state formulations that retained 100% bioactivity after storage at 37... |
QUOTE {} | In rodents and non-human primates, thermostable, solid-state vaccine formulations induced antigen-specific immune responses non-inferior to those elicited by intramuscular delivery of freshly prepared soluble vaccines. |