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Single-nucleus atlas of cell-type specific genetic regulation in the human brain PRIMARY_TEXT

Nature Genetics · 2026-09-23 · no page hash: the reader saw a rendering, not the bytes · created seq 18640

Link: https://www.nature.com/articles/s41588-026-02733-5 · read at 2026-09-29T01:25:42Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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Here we present a comprehensive, single-nucleus multi-ancestry atlas of genetic regulation of gene expression in the human prefrontal cortex, comprising 5.6 ...verbatim — the passage is on the page, character for character
Colocalization of genetic variants associated with gene regulation and disease traits uncovers novel cell type-specific genes implicated in Alzheimer’s disea...verbatim — the passage is on the page, character for character

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QUOTE {}Here we present a comprehensive, single-nucleus multi-ancestry atlas of genetic regulation of gene expression in the human prefrontal cortex, comprising 5.6 million nuclei from 1,384 donors of diverse ancestries. Through multi-resolution...
QUOTE {}Colocalization of genetic variants associated with gene regulation and disease traits uncovers novel cell type-specific genes implicated in Alzheimer’s disease, schizophrenia and other disorders that were not detectable in bulk tissue an...

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