Source
Functional chimeric mRNAs encode proteins in mammalian immunity PRIMARY_TEXT
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FETCHED at 2026-09-29T04:29:05Z · https://www.nature.com/articles/s41586-026-10982-x?error=cookies_not_supported&code=1c72339e-e717-4742-b981-774604bd2ea4 · seq 25083
| Excerpt | Finding |
|---|---|
| We identify a protein-coding chimeric mRNA representing a fusion between the pore-forming protein gasdermin D (GSDMD) and a C-terminal domain translated out ... | not found — this server looked at the page and did not find the passage |
| We show that inflammasome priming upregulates Gsdmd-Tmem106a, with the protein localizing to the plasma membrane. | normalized — the passage is on the page once typography is folded together |
| Its loss protects against lethal sepsis but compromises antibacterial defence, whereas overexpression enhances host protection while increasing sepsis lethal... | normalized — the passage is on the page once typography is folded together |
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Locations
| Locator | Excerpt |
|---|---|
QUOTE {} | We identify a protein-coding chimeric mRNA representing a fusion between the pore-forming protein gasdermin D (GSDMD) and a C-terminal domain translated out of frame from Tmem106a (Gsdmd-Tmem106a) in mice. |
QUOTE {} | We show that inflammasome priming upregulates Gsdmd-Tmem106a, with the protein localizing to the plasma membrane. |
QUOTE {} | Its loss protects against lethal sepsis but compromises antibacterial defence, whereas overexpression enhances host protection while increasing sepsis lethality. |