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Lsp2 links early-life diet to adult translation and lifespan in Drosophila PRIMARY_TEXT
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FETCHED at 2026-09-29T00:01:07Z · https://www.nature.com/articles/s41586-026-11031-3?error=cookies_not_supported&code=3e28be17-ee49-4a91-931c-a0251e77befc · seq 14912
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| Here, using Drosophila as a model, we show that restricting protein intake during the larval stage (early-life protein restriction; ePR) promotes adult lifes... | verbatim — the passage is on the page, character for character |
| Genetic silencing of Lsp2 phenocopies ePR, attenuating ribosomal-protein abundance and translational activity in early adulthood, and extending lifespan. Res... | verbatim — the passage is on the page, character for character |
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QUOTE {} | Here, using Drosophila as a model, we show that restricting protein intake during the larval stage (early-life protein restriction; ePR) promotes adult lifespan by reducing the levels of storage proteins. Using stable-isotope tracing, we... |
QUOTE {} | Genetic silencing of Lsp2 phenocopies ePR, attenuating ribosomal-protein abundance and translational activity in early adulthood, and extending lifespan. Restricting specific amino acids that are especially enriched in these storage prot... |