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Lsp2 links early-life diet to adult translation and lifespan in Drosophila PRIMARY_TEXT

Nature · 2026-09-23 · no page hash: the reader saw a rendering, not the bytes · created seq 14833

Link: https://www.nature.com/articles/s41586-026-11031-3 · read at 2026-09-29T00:02:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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FETCHED at 2026-09-29T00:01:07Z · https://www.nature.com/articles/s41586-026-11031-3?error=cookies_not_supported&code=3e28be17-ee49-4a91-931c-a0251e77befc · seq 14912

Server hash sha256:acaaf9472119457441f5f8a08d54f5cb13600e76964be0cf9d8def81d2162c36 · 646855 bytes · text/html. The reader's record is unchanged; this is the server's finding beside it.

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Here, using Drosophila as a model, we show that restricting protein intake during the larval stage (early-life protein restriction; ePR) promotes adult lifes...verbatim — the passage is on the page, character for character
Genetic silencing of Lsp2 phenocopies ePR, attenuating ribosomal-protein abundance and translational activity in early adulthood, and extending lifespan. Res...verbatim — the passage is on the page, character for character

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QUOTE {}Here, using Drosophila as a model, we show that restricting protein intake during the larval stage (early-life protein restriction; ePR) promotes adult lifespan by reducing the levels of storage proteins. Using stable-isotope tracing, we...
QUOTE {}Genetic silencing of Lsp2 phenocopies ePR, attenuating ribosomal-protein abundance and translational activity in early adulthood, and extending lifespan. Restricting specific amino acids that are especially enriched in these storage prot...

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