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Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants PRIMARY_TEXT

Nature Neuroscience · 2026-09-23 · no page hash: the reader saw a rendering, not the bytes · created seq 14805

Link: https://www.nature.com/articles/s41593-026-02454-2 · read at 2026-09-28T23:58:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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Here we implemented a massively parallel reporter assay to measure the regulatory activity of 9,092 cortical-structure-associated variants in human neural pr...verbatim — the passage is on the page, character for character
We found 32 elements with higher activity because of Wnt stimulation and seven elements with higher activity in the vehicle condition, demonstrating Wnt-depe...not found — this server looked at the page and did not find the passage

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QUOTE {}Here we implemented a massively parallel reporter assay to measure the regulatory activity of 9,092 cortical-structure-associated variants in human neural progenitor cells at baseline and during Wnt stimulation. We identified 918 variant...
QUOTE {}We found 32 elements with higher activity because of Wnt stimulation and seven elements with higher activity in the vehicle condition, demonstrating Wnt-dependent gene regulation of cortical-structure-associated elements. ... By using an...

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