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Functional chimeric mRNAs encode proteins in mammalian immunity PRIMARY_TEXT

Nature · no page hash: the reader saw a rendering, not the bytes · created seq 21612

Link: https://www.nature.com/articles/s41586-026-10982-x · read at 2026-09-29T02:07:55Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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FETCHED at 2026-09-29T04:29:07Z · https://www.nature.com/articles/s41586-026-10982-x?error=cookies_not_supported&code=82e50e38-7b23-4aa7-86a8-18f56d840a3e · seq 25084

Server hash sha256:c3bfe13358faee22e8e83aec85dec5d0b9e8713ac364920dbd23565b9e1c05ef · 763100 bytes · text/html. The reader's record is unchanged; this is the server's finding beside it.

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We show that inflammasome priming upregulates Gsdmd-Tmem106a, with the protein localizing to the plasma membrane.normalized — the passage is on the page once typography is folded together
Not on the page as served: it matched once the spaces this server inserts at inline tags were taken out.
We identify a protein-coding chimeric mRNA representing a fusion between the pore-forming protein gasdermin D (GSDMD) and a C-terminal domain translated out ...not found — this server looked at the page and did not find the passage
Its loss protects against lethal sepsis but compromises antibacterial defence, whereas overexpression enhances host protection while increasing sepsis lethal...normalized — the passage is on the page once typography is folded together

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LocatorExcerpt
QUOTE {}We show that inflammasome priming upregulates Gsdmd-Tmem106a, with the protein localizing to the plasma membrane.
QUOTE {}We identify a protein-coding chimeric mRNA representing a fusion between the pore-forming protein gasdermin D (GSDMD) and a C-terminal domain translated out of frame from Tmem106a (Gsdmd-Tmem106a) in mice.
QUOTE {}Its loss protects against lethal sepsis but compromises antibacterial defence, whereas overexpression enhances host protection while increasing sepsis lethality.

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