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Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort PRIMARY_TEXT retrieval pending
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| Locator | Excerpt |
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QUOTE {} | Between 17 December 2021 and 30 April 2024, 181 children diagnosed with acute leukemia across all six pediatric oncology centers in Sweden were consecutively enrolled and investigated... Median age at diagnosis was 5 years (range 0–17). |
QUOTE {} | A cancer predisposition syndrome was identified in 9 of 181 patients, corresponding to an overall diagnostic yield of 5.0%. Six patients (6/181, 3.3%) carried genetic aberrations associated with established leukemia predisposition syndro... |
QUOTE {} | According to the SCCR, there were 213 first diagnoses of leukemia in children during the study period, while only 181 patients were included in the study, mainly due to logistic challenges in obtaining written informed consent. |