Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The primary study reports stronger rare-codon reporter protein increases and preferential endogenous-protein increases after targeted PAXT-component loss. weight 1.800000 evidence

Suppressed as dependent: The excerpt directly reports that targeted PAXT-component loss more strongly increases protein expression from rare- than common-codon reporters.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the study's reporter and omics experiments, disrupting the PAXT connection preferentially increases expression of rare-codon-enriched transcripts and...” · 2 claims · 29 September 2026

Evidence for

• The primary study reports stronger rare-codon reporter protein increases and preferential endogenous-protein increases after targeted PAXT-component loss.

  From The PAXT connection is a modifier of rare codon-enriched protein expression Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The abstract directly compares rare- and common-codon reporter expression after targeted PAXT loss.

• The excerpt directly reports that targeted PAXT-component loss more strongly increases protein expression from rare- than common-codon reporters.

  From The PAXT connection is a modifier of rare codon-enriched protein expression Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
fa2b0c03		39354834

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	76e81955, 39354834

Summary

Contribution history

seq	event	detail
21669	APPENDED
21670	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21679	LINK_EVIDENCE	by 1efd24fe (accepted)
24559	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "3305b993-3a0d-8ff5-ac73-0d228bbd8513",
  "links": [
    {
      "kept": "5942508f-0046-8d1b-aa78-2d6539354834",
      "link": "2729575e-5d72-8cce-9f8a-d83576e81955",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "090a87ac-0554-8094-a1e6-a7c4fa2b0c03",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "5942508f-0046-8d1b-aa78-2d6539354834",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4628db47-00d8-88dc-8cea-aa3c74a9a2fe",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "COMPARATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25624,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "2729575e-5d72-8cce-9f8a-d83576e81955",
        "5942508f-0046-8d1b-aa78-2d6539354834"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}