As of snapshot 27745 under ledger-default@0.3.0. Counts by assessment state, descriptive only: no topic is scored.
2 Insufficient evidence10 Leans supported88 Supported
| Claim | Type | Assessment |
|---|
| Mid-gestation pregnancy in female mice was associated with region-specific remodeling of brain lipidome territories, especially in white matter and cortical layer 4. | OBSERVATIONAL | Supported |
| Chemical dissociation of cytosolic myddosomes disrupted inflammatory activities of TLR-stimulated cells in vitro and in vivo. | CAUSAL | Leans supported |
| TRAM-dependent long-lasting myddosome activity determines hours-long NF-κB activation and secondary response gene expression in the studied TLR pathways. | CAUSAL | Leans supported |
| In macrophage models, TRAM regulates myddosome assembly by dissociating MyD88 from the TLR–TIRAP complex, enabling maturation of receptor-free cytosolic myddosomes and downstream signaling. | CAUSAL | Leans supported |
| The study's GWAS, cell-interaction analyses, and mouse validation indicate that peripheral nerves fine-tune maxilla shape during embryonic development. | CAUSAL | Leans supported |
| In the facial atlas, gene-expression associations with facial traits were strongest in early mesenchymal progenitor cells and became more region restricted over development. | OBSERVATIONAL | Supported |
| The study created a multimodal facial atlas across embryonic weeks 6–11 using single-cell transcriptomics, chromatin accessibility, and spatial transcriptomics, and characterized 56 cell states. | QUANTITATIVE | Supported |
| In the study's trisomy 21 samples, fibroblast chemokine expression was reduced while JAK–STAT signaling was enhanced. | OBSERVATIONAL | Supported |
| The meningeal atlas data support a yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages described as primed for barrier immunity. | INTERPRETIVE | Supported |
| The study constructed a paired single-nuclei RNA and chromatin-accessibility atlas of human meningeal development from 6 to 21 postconception weeks across cranial regions, integrated with spatial transcriptomics. | OBSERVATIONAL | Supported |
| The Dongoconodon specimen preserved multiple tooth generations across incisors, canines, premolars and molars, described as the first mammal known to show repeated replacement across all four broad tooth categories. | OBSERVATIONAL | Supported |
| The study reports that Methanothermococcus okinawensis carbon and energy metabolism in the simulated system was fueled by abiotic H2 from mineral-water reactions. | OBSERVATIONAL | Supported |
| Transcriptomic analysis associated growth under extreme CO2 scarcity in the simulated Enceladus chemistry with overexpression of the reductive acetyl-CoA CO2-fixation pathway. | OBSERVATIONAL | Supported |
| In simulated Enceladus-like ocean chemistry, Methanothermococcus okinawensis grew at alkaline conditions up to pH 11, beyond its previously known pH limit. | OBSERVATIONAL | Supported |
| Dongoconodon platycauda had expanded feet resembling webbed platypus feet and a flattened tapering tail interpreted as adaptations for swimming and steering. | OBSERVATIONAL | Supported |
| Dongoconodon platycauda, an approximately 125-million-year-old Early Cretaceous mammal from China, is the earliest confirmed swimming mammal discovered to date. | HISTORICAL | Supported |
| The study reported that mammalian cells can use S₈ to produce hydropersulfides that act as antioxidants. | OBSERVATIONAL | Supported |
| A 2026 study detected cyclooctasulfur (S₈) in both mouse and human cells, with high levels in mitochondria and lipid droplets. | OBSERVATIONAL | Supported |
| The DILT family of nine-residue amphiphilic peptides assembles into hexagonal nanofibrils with continuous approximately 5-nm solvent-accessible channels through cross-beta-dimer, trimeric-junction, and inversion motifs. | OBSERVATIONAL | Supported |
| A 2026 study used digital and microscopic analysis to examine 18 mammoth-ivory figurines from Mizyn, Ukraine. | OBSERVATIONAL | Supported |
| Incendiamoeba cascadensis can remain active at temperatures up to 64°C. | QUANTITATIVE | Supported |
| Incendiamoeba cascadensis can reproduce by cellular division at temperatures up to 63°C. | QUANTITATIVE | Supported |
| When the ART system was placed into E. coli, its array split into distinct short RNAs. | OBSERVATIONAL | Supported |
| In published data from a jumbo phage infecting Staphylococcus bacteria, RNA from an ART array accounted for as much as 8% of the virus’s RNA. | QUANTITATIVE | Supported |
| Across four widespread permafrost soil types over 389 days, realistic active-layer inocula increased CO2 or N2O production less than a diverse multifunctional microbial community and did so inconsistently. | OBSERVATIONAL | Supported |
| The 2011 tsunami and its backwash brought marine Japan Sea stickleback and freshwater threespine stickleback into the same newly formed freshwater pond in Iwate, resulting in interspecific hybridization. | HISTORICAL | Supported |
| The study reported that Iron Age reoccupation at Bakr Awa integrated divergent preceding Bronze Age ancestries rather than replacing them. | COMPARATIVE | Supported |
| The study reported substantial Bronze Age genetic heterogeneity at Bakr Awa, including Anatolian, Levantine, and Caucasus/Yamnaya-related ancestry influences. | OBSERVATIONAL | Supported |
| The study analyzed DNA from 17 Bronze- and Iron-Age individuals at Bakr Awa in northeastern Iraq. | QUANTITATIVE | Supported |
| In a corpus of 100 computational-biology papers, Paper2Agent successfully agentified 74 papers and produced 599 proposed tools, of which 593 passed automated validation. | QUANTITATIVE | Leans supported |
| The northern New Mexico thinning-and-prescribed-burning treatments had less impact on beetle communities than clear-cutting or high-severity wildfire, according to the study. | COMPARATIVE | Leans supported |
| The northern New Mexico restoration treatments were associated with 21 common beetle species increasing and 35 declining in the post-treatment sub-canopy environment. | QUANTITATIVE | Supported |
| In a six-year northern New Mexico mixed-conifer case study, thinning followed by prescribed broadcast burning significantly changed surface-active beetle community composition. | OBSERVATIONAL | Supported |
| The study trained GPN-Star for five model organisms beyond humans, demonstrating robustness and generalizability across those species. | OBSERVATIONAL | Supported |
| In the study, GPN-Star achieved state-of-the-art performance across coding and non-coding human variant-effect prediction tasks. | OBSERVATIONAL | Supported |
| GPN-Star is a phylogeny-aware genomic language model that uses whole-genome alignments and species trees to model evolutionary relationships. | DEFINITIONAL | Supported |
| In the study, hindbrain activity was necessary for mesenteric-artery constriction and gut blood-flow reduction during hypoxia in zebrafish. | CAUSAL | Supported |
| In larval zebrafish, WHOLISTIC revealed rhythmic travelling waves along the renal nephron and previously unknown muscle–organ interactions. | OBSERVATIONAL | Supported |
| The study developed WHOLISTIC, a method for imaging second-timescale activity across the entire vertebrate body at cellular resolution. | OBSERVATIONAL | Supported |
| In the study, fractal dimension 2.41 and height range 7.96 cm produced oyster densities 35% higher than the maximum-dimension, 12-cm-height configuration. | QUANTITATIVE | Supported |
| The study found that oyster settlement and survival were greatest at particular combinations of reef fractal dimension and height that minimized predation. | CAUSAL | Supported |
| The study deployed 480 artificial oyster-habitat replicates spanning 16 geometries across three estuaries, with half caged against predation. | QUANTITATIVE | Supported |
| In the study's transcriptomics-proteomics analysis, loss of a PAXT component preferentially increases endogenous proteins encoded by poorly expressed, long mRNAs enriched in rare codons. | OBSERVATIONAL | Supported |
| In the study's reporter assays, targeted loss of a PAXT component preferentially increases protein expression from rare-codon-enriched reporters compared with common-codon-enriched reporters. | COMPARATIVE | Supported |
| In Arabidopsis seedlings, MCA1 mechanosensitive channels contribute to long-distance wound-signal communication between lateral roots. | CAUSAL | Leans supported |
| In Arabidopsis seedlings, mechanical injury to one lateral root produces membrane depolarizations in neighboring lateral roots within milliseconds. | OBSERVATIONAL | Supported |
| In mouse experiments, loss of GSDMD–TMEM106A protected against lethal sepsis but weakened antibacterial defence, while overexpression had opposite effects. | COMPARATIVE | Supported |
| In the study, inflammasome priming upregulated Gsdmd-Tmem106a and its protein localized to the plasma membrane. | OBSERVATIONAL | Supported |
| The study identified a protein-coding Gsdmd-Tmem106a chimeric mRNA in mouse macrophage immunity. | OBSERVATIONAL | Supported |
| In the study, deleting RANKL in lymphoid tissue organizer cells caused an almost complete absence of Thetis-cell subset TC I. | CAUSAL | Leans supported |
| In the study, PU.1 ablation in RORγt+ cells caused an almost complete absence of Thetis-cell subsets TC I–IV without impairing LTi cells. | COMPARATIVE | Supported |
| The study reported that mouse Thetis cells descend from the common lymphoid progenitor despite transcriptional similarity to conventional dendritic cells. | OBSERVATIONAL | Supported |
| In the study's mouse model of lung protease hypersensitivity, memory of the initial event was stored in CCL11-expressing adventitial stromal cells; Ccl11 accessibility increased with papain exposure through IL-4/IL-13 and was blocked by interferon-γ. | OBSERVATIONAL | Supported |
| The study reported that reef-building coral microbiomes had biosynthetic potential rivaling or surpassing traditional natural-product sources such as sponges. | COMPARATIVE | Leans supported |
| In the study’s dataset, only 10% of 4,224 microbial species and less than 1% of 645 Tara Pacific-exclusive species had prior genomic information. | QUANTITATIVE | Supported |
| The study analyzed microbial genomes reconstructed from 820 reef-building coral samples collected at 99 Pacific reefs across 32 islands. | QUANTITATIVE | Supported |
| The study's analysis of APN orthologues from 93 species found restricted EriCoV receptor tropism, primarily using hedgehog APN and, to a lesser extent, felid APN. | QUANTITATIVE | Supported |
| In the study's tumour models, abrupt stress increases rather than cumulative or peak stress magnitude determined epithelial–mesenchymal transition induction. | OBSERVATIONAL | Supported |
| The study reported that fungal P450 enzymes PpnB and NseB catalyzed oxidative C(sp2)-methyl removal from O-prenyl l-tyrosine to produce O-homoallenyl l-tyrosine and O-but-2-ynyl l-tyrosine, respectively. | OBSERVATIONAL | Supported |
| Across the past two decades, vegetation productivity overcompensation after late-spring frost intensified as warming reduced frost-related losses and increased regrowth. | COMPARATIVE | Supported |
| In manipulative grassland frost experiments, warmer temperatures and higher species diversity strengthened vegetation's post-frost compensatory responses. | CAUSAL | Leans supported |
| In the study population, most Gasterosteus nipponicus genomic material was purged within ten generations after the tsunami. | QUANTITATIVE | Supported |
| The study reported early purging of Gasterosteus nipponicus alleles at reproductive-isolation loci, followed by broader genome-wide purging except at several loci. | OBSERVATIONAL | Supported |
| The study used nine years of genomic monitoring to examine a tsunami-induced hybrid stickleback population and its post-hybridization allele changes. | HISTORICAL | Supported |
| The study reported increased activity in optic-tectum and thalamic visual neurons when glassfish viewed escaping virtual conspecifics. | OBSERVATIONAL | Supported |
| The study reported that Danionella cerebrum can mediate collective escape through an individual fish’s visual perception of escaping social partners. | OBSERVATIONAL | Supported |
| In aged-heart models, cardiac Vegfc overexpression or Il33 silencing restored lymphatic density and tissue homeostasis, identifying the VEGFC–IL-33 axis as a potential target for age-related cardiac dysfunction. | CAUSAL | Supported |
| Aging reduced cardiac lymphatic-vessel density in humans and mice, and experimentally reducing cardiac lymphatics in young mice recapitulated inflammation and impaired lymphatic integrity associated with cardiac aging. | CAUSAL | Supported |
| In streptomycin-treated mouse models of Salmonella Typhimurium infection, prophylactic colonization with engineered E. coli producing obligately lytic P22* phage reduced pathogen colonization and improved survival. | OBSERVATIONAL | Supported |
| Strontium-isotope comparisons identified 17 non-local individuals among 199 Bronze Age individuals from six archaeological sites in central and southern Greece, with childhood origins potentially elsewhere in Greece. | QUANTITATIVE | Supported |
| The combinatorial relationships among regulatory motifs were largely species-specific, and models trained on individual cell types within a family lost cross-species predictive power, indicating rapidly evolving cell-type regulatory syntax. | COMPARATIVE | Supported |
| Across flatworms and vertebrates, hundreds of accessibility-dictating DNA motifs formed conserved vocabularies associated with particular cell-type families, and models trained in one species could predict family-level chromatin accessibility in distant species. | COMPARATIVE | Supported |
| The study characterized Bianfu Cave as a Denisovan locality with the most abundant Denisovan remains outside Denisova Cave in Siberia. | OBSERVATIONAL | Supported |
| The study identified three hominin fossils from approximately 167–134 thousand years ago and reported proteomic confirmation of those bones and two excavated teeth as Denisovan. | OBSERVATIONAL | Supported |
| The study screened more than 60,000 Bianfu Cave bone fragments, selecting 76 for zooarchaeology by mass spectrometry and 17 for proteomic sequencing. | QUANTITATIVE | Supported |
| The Hindu Kush Heremites lineage was estimated to have split from related western clades in the Late Miocene approximately 10 million years ago and is currently known from two southern-Hindu-Kush foothill localities. | QUANTITATIVE | Supported |
| Mitochondrial, nuclear, phylogenetic, and morphological evidence supported recognizing the Hindu Kush lineage of Heremites as a distinct new species. | COMPARATIVE | Supported |
| In experimental renal fibrosis, SRPX2 interacted with IRP1 and disrupted iron-regulatory signaling, and iron dextran supplementation alleviated UUO-induced renal fibrosis. | CAUSAL | Supported |
| SRPX2 expression was elevated in CKD patient kidney and serum samples and in experimental renal-fibrosis models, while global or tubular-epithelial deletion of Srpx2 attenuated kidney injury and fibrosis in mice. | CAUSAL | Supported |
| The study reported global geographical aggregation and ongoing positive selection of TaNPF7.6-A1mod during wheat breeding. | OBSERVATIONAL | Supported |
| The study identified a TaEIL3–TaJAZ1–TaNPF7.6-A1 regulatory pathway affecting nitrogen-use efficiency in wheat. | OBSERVATIONAL | Supported |
| In the study, the TaNPF7.6-A1mod wheat allele had higher transcription and nitrate-transport activity than TaNPF7.6-A1lan and was associated with greater nitrogen-use efficiency. | OBSERVATIONAL | Supported |
| ArmA is a glycosyl hydrolase specific for archaeal peptidoglycan, and the study found that it cleaves archaeal cell-wall material at the site of methanogen cell division. | OBSERVATIONAL | Insufficient evidence |
| In the same skin-infection model, a later neutrophil-recruitment phase depended on Toll-like receptor and CXCL2 signaling, marking a transition to canonical pathogen-driven innate immunity. | CAUSAL | Supported |
| In a skin-infection model with pathogenic bacteria and fungi, microbial adhesion initiated an early PRR-independent neutrophil-recruitment phase by engaging Piezo1 and promoting leukotriene B4, interleukin-1α, and CXCL1 signaling. | CAUSAL | Supported |
| In the study, gradual acidification produced weaker phenotypic and genomic shifts that aligned more closely with natural ocean conditions. | OBSERVATIONAL | Supported |
| In the study, abrupt acidification produced diatom growth and carbon-fixation responses up to 15% larger than under gradual acidification. | QUANTITATIVE | Supported |
| The study compared abrupt and gradual CO2 increases from 440 to 1000 ppm across 1100 generations of the marine diatom Chaetoceros muelleri. | QUANTITATIVE | Supported |
| A global mitogenome framework reconstructed about 20,000 mitochondrial metagenome-assembled genomes from 3,400 metagenomes spanning 362 lakes on seven continents, enabling species-resolved freshwater microeukaryote inventories. | QUANTITATIVE | Supported |
| Gap soils had more densely connected but topologically simplified microbial co-occurrence networks with fewer keystone taxa, and predicted functional potential was associated with both keystone structure and whole-community structure rather than keystone structure alone. | COMPARATIVE | Supported |
| Soil bacterial temporal turnover and seasonal community divergence were greater in forest gaps than in adjacent closed-canopy soils in a subtropical karst forest. | COMPARATIVE | Supported |
| Within marine ecosystems, species asynchrony was the strongest predictor of fish-mediated nutrient-dynamics stability, with higher synchrony associated with destabilization. | COMPARATIVE | Supported |
| Across coral reef, mangrove, seagrass, and kelp ecosystems, fish species richness positively predicted the temporal stability of consumer-mediated nutrient dynamics measured as nitrogen supply via excretion. | COMPARATIVE | Supported |
| The study identified Bianfu Cave as a Denisovan locality with the most abundant Denisovan remains outside Denisova Cave in Siberia at the time of the report. | OBSERVATIONAL | Supported |
| In the study’s Bayesian protein phylogenies, each of the five Bianfu Cave samples formed a monophyletic group with Denisova 3 with posterior probability of 100%. | QUANTITATIVE | Supported |
| Proteomic analysis identified five Denisovan specimens from Bianfu Cave: three newly identified hominin bone fragments and two previously excavated hominin teeth. | OBSERVATIONAL | Supported |
| The chickpea crossover study found evidence that oral bacterial strains reached the ileum after the meal, where their abundance was associated with local metabolites and PYY responses. | OBSERVATIONAL | Supported |
| In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several mutations caused cross-resistance, while N6 and 1–18 largely retained activity. | QUANTITATIVE | Insufficient evidence |
| A multi-ancestry human prefrontal-cortex atlas analyzed 5.6 million nuclei from 1,384 donors and identified genetic regulation for 14,258 genes across eight cell classes and 27 subclasses. | QUANTITATIVE | Supported |
| The Canjuers locality preserves the youngest Jurassic turtle fauna currently known from Europe. | COMPARATIVE | Supported |
Galedra