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Science

Natural science, its methods, and its findings.

Biology 154 Medicine 97 Neuroscience 27 Psychology 24 Physics 57 Chemistry 59 Earth science 59 Astronomy and space 54

As of snapshot 27745 under ledger-default@0.3.0. Counts by assessment state, descriptive only: no topic is scored. 12 Leans supported87 Supported1 Unresolved

ClaimTypeAssessment
Mid-gestation pregnancy in female mice was associated with region-specific remodeling of brain lipidome territories, especially in white matter and cortical layer 4.OBSERVATIONALSupported
In an adult mouse brain atlas, spatial distributions of 172 measured lipids formed 539 lipidome-defined territories called lipizones.OBSERVATIONALSupported
In pregnant female mice, increased SK3 activity in dorsal-raphe serotonin neurons reduced firing and promoted food-craving-like behavior; deleting SK3 reduced that behavior.CAUSALLeans supported
In mice and pigs with traumatic brain injury, dynamic compressive tibial axial loading promoted motor and cognitive recovery, and osteocyte Piezo1 was required for the benefit in mice.CAUSALLeans supported
Chemical dissociation of cytosolic myddosomes disrupted inflammatory activities of TLR-stimulated cells in vitro and in vivo.CAUSALLeans supported
TRAM-dependent long-lasting myddosome activity determines hours-long NF-κB activation and secondary response gene expression in the studied TLR pathways.CAUSALLeans supported
In macrophage models, TRAM regulates myddosome assembly by dissociating MyD88 from the TLR–TIRAP complex, enabling maturation of receptor-free cytosolic myddosomes and downstream signaling.CAUSALLeans supported
The study's GWAS, cell-interaction analyses, and mouse validation indicate that peripheral nerves fine-tune maxilla shape during embryonic development.CAUSALLeans supported
In the facial atlas, gene-expression associations with facial traits were strongest in early mesenchymal progenitor cells and became more region restricted over development.OBSERVATIONALSupported
The study created a multimodal facial atlas across embryonic weeks 6–11 using single-cell transcriptomics, chromatin accessibility, and spatial transcriptomics, and characterized 56 cell states.QUANTITATIVESupported
In the study's trisomy 21 samples, fibroblast chemokine expression was reduced while JAK–STAT signaling was enhanced.OBSERVATIONALSupported
The meningeal atlas data support a yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages described as primed for barrier immunity.INTERPRETIVESupported
The study constructed a paired single-nuclei RNA and chromatin-accessibility atlas of human meningeal development from 6 to 21 postconception weeks across cranial regions, integrated with spatial transcriptomics.OBSERVATIONALSupported
The study identifies three alteration episodes in the Jezero Margin unit: carbonate-rich ridge formation from CO2-rich fluids, later carbonate remobilization with silica precipitation, and late fluorite-bearing calcium-sulfate veins from fluids through younger fractures.HISTORICALSupported
Lower Jezero Margin-unit exposures show a complex history of water-rock interaction, unlike the high-elevation exposures described in the study.OBSERVATIONALSupported
At elevations above approximately −2350 m, the Jezero Margin unit has texture and chemistry indicative of slowly cooled crystalline olivine-rich rock without significant water exposure.OBSERVATIONALSupported
The Dewar-region evidence implies that the Moon had an internally generated magnetic field stronger than 10 μT around 4.2 billion years ago.QUANTITATIVELeans supported
Joint gravity and magnetic observations identify a roughly 60-km-wide, 9-km-deep dense, strongly magnetized body beneath the Moon’s Dewar region, interpreted as a buried volcanic complex.OBSERVATIONALSupported
The Dongoconodon specimen preserved multiple tooth generations across incisors, canines, premolars and molars, described as the first mammal known to show repeated replacement across all four broad tooth categories.OBSERVATIONALSupported
The study reports that Methanothermococcus okinawensis carbon and energy metabolism in the simulated system was fueled by abiotic H2 from mineral-water reactions.OBSERVATIONALSupported
Transcriptomic analysis associated growth under extreme CO2 scarcity in the simulated Enceladus chemistry with overexpression of the reductive acetyl-CoA CO2-fixation pathway.OBSERVATIONALSupported
In simulated Enceladus-like ocean chemistry, Methanothermococcus okinawensis grew at alkaline conditions up to pH 11, beyond its previously known pH limit.OBSERVATIONALSupported
Dongoconodon platycauda had expanded feet resembling webbed platypus feet and a flattened tapering tail interpreted as adaptations for swimming and steering.OBSERVATIONALSupported
Dongoconodon platycauda, an approximately 125-million-year-old Early Cretaceous mammal from China, is the earliest confirmed swimming mammal discovered to date.HISTORICALSupported
The 176Lu+ comparison became statistically limited after approximately 200 hours of averaging, with measurement instability of 4.8×10⁻¹⁶(τ/s)⁻¹ᐟ².QUANTITATIVESupported
Direct correlation spectroscopy reported a relative frequency agreement of −2.4×10⁻¹⁹ with ±5.7×10⁻¹⁹ statistical and ±1.0×10⁻¹⁹ systematic uncertainties.QUANTITATIVESupported
Two independent 176Lu+ single-ion optical references were reported with total systematic uncertainties of 1.1×10⁻¹⁹ and 1.4×10⁻¹⁹, and 9.6×10⁻²⁰ for their difference.QUANTITATIVESupported
The study reported that mammalian cells can use S₈ to produce hydropersulfides that act as antioxidants.OBSERVATIONALSupported
A 2026 study detected cyclooctasulfur (S₈) in both mouse and human cells, with high levels in mitochondria and lipid droplets.OBSERVATIONALSupported
The report states that N-terminal sequence perturbations preserve the DILT hexagonal lattice while modulating pore hydration and surface chemistry.COMPARATIVESupported
Cryo-electron microscopy reportedly resolved DILT fibrils at 2.9–4.0 Å, with a repeating unit of 12 peptide chains and C6 symmetry.QUANTITATIVESupported
The DILT family of nine-residue amphiphilic peptides assembles into hexagonal nanofibrils with continuous approximately 5-nm solvent-accessible channels through cross-beta-dimer, trimeric-junction, and inversion motifs.OBSERVATIONALSupported
A 2026 study used digital and microscopic analysis to examine 18 mammoth-ivory figurines from Mizyn, Ukraine.OBSERVATIONALSupported
Incendiamoeba cascadensis can remain active at temperatures up to 64°C.QUANTITATIVESupported
Incendiamoeba cascadensis can reproduce by cellular division at temperatures up to 63°C.QUANTITATIVESupported
The STEP analysis found no significant treatment-by-metabolic-syndrome interaction for cardiovascular or safety outcomes, although hypotension was numerically more frequent with intensive treatment in the highest tertile.QUANTITATIVESupported
Over a median 3.32-year follow-up, intensive systolic blood-pressure lowering was associated with lower primary cardiovascular-outcome risk than standard treatment across metabolic-syndrome tertiles; the largest reduction was in the middle tertile (HR 0.66, 95% CI 0.44–0.99).QUANTITATIVESupported
A post hoc STEP-trial analysis included 8,231 participants with complete metabolic-syndrome severity data and used an age-, sex-, and ethnicity-specific scoring model.OBSERVATIONALSupported
In the total randomized sample, 12-month symptom severity did not differ significantly between PROTECTtraining and PROTECTinfo, and secondary outcomes also did not differ significantly.QUANTITATIVESupported
Among 205 adolescents at high risk for gaming disorder or unspecified internet use disorder, PROTECTtraining had lower 12-month symptom severity than PROTECTinfo, with between-group Cohen’s d −0.30 (95% CI −0.55 to −0.05).QUANTITATIVESupported
PROTECTconfirm randomized 1,793 students in 44 Baden-Württemberg secondary schools to four weekly 90-minute sessions of CBT-based PROTECTtraining or structurally parallel media-literacy PROTECTinfo.OBSERVATIONALSupported
At post-intervention, One Step Back participants reported lower depression scores by 5.54 points and higher well-being by 4.53 points than active controls.QUANTITATIVESupported
At post-intervention, One Step Back participants had higher self-reported decentering than active controls by 4.16 points (95% CI 1.85–6.51; p=0.002; Cohen’s d=0.61).QUANTITATIVESupported
In a two-arm randomized trial, a 5-week One Step Back psychological-decentering program was compared with an active physical-and-cognitive-exercise control among 114 UK secondary-school adolescents at risk of depression.OBSERVATIONALSupported
When the ART system was placed into E. coli, its array split into distinct short RNAs.OBSERVATIONALSupported
In published data from a jumbo phage infecting Staphylococcus bacteria, RNA from an ART array accounted for as much as 8% of the virus’s RNA.QUANTITATIVESupported
The University of Arizona report says researchers manually searched publicly available JWST spectra from hundreds of galaxies and identified three with absorption patterns indicating carbon, oxygen and silicon.OBSERVATIONALSupported
The study’s joint H2O and CO2 constraints favored near-equilibrium chemistry, approximately 10× solar metallicity, and a 3-sigma upper limit of C/O below 0.52.QUANTITATIVESupported
The study reported tentative retrieval evidence for H2S in HAT-P-1 b’s atmosphere, with log10 Bayes factor 1.4.QUANTITATIVESupported
The study reported strong retrieval evidence for H2O and CO2 in HAT-P-1 b’s atmosphere, with log10 Bayes factors of 8.9 and 52.3, respectively.QUANTITATIVESupported
Across four widespread permafrost soil types over 389 days, realistic active-layer inocula increased CO2 or N2O production less than a diverse multifunctional microbial community and did so inconsistently.OBSERVATIONALSupported
In the trial, closed-loop auditory stimulation enhanced stimulation-evoked slow-wave and fast-spindle activity while preserving sleep architecture and subjective sleep quality.COMPARATIVESupported
In the trial, closed-loop auditory stimulation significantly improved overnight word-pair consolidation, with Cohen’s dz = 0.42 and p = 0.04.QUANTITATIVESupported
A randomized, double-blind, placebo-controlled crossover trial tested one night of closed-loop auditory stimulation against sham stimulation in 37 patients with biomarker-confirmed early symptomatic Alzheimer disease.QUANTITATIVESupported
The 2011 tsunami and its backwash brought marine Japan Sea stickleback and freshwater threespine stickleback into the same newly formed freshwater pond in Iwate, resulting in interspecific hybridization.HISTORICALSupported
The study reported that Iron Age reoccupation at Bakr Awa integrated divergent preceding Bronze Age ancestries rather than replacing them.COMPARATIVESupported
The study reported substantial Bronze Age genetic heterogeneity at Bakr Awa, including Anatolian, Levantine, and Caucasus/Yamnaya-related ancestry influences.OBSERVATIONALSupported
The study analyzed DNA from 17 Bronze- and Iron-Age individuals at Bakr Awa in northeastern Iraq.QUANTITATIVESupported
Among countries larger than 50,000 km² in the study, Germany had the highest precipitation-gauge density at 22.4 gauges per 1,000 km².QUANTITATIVESupported
Among continents in the study, Europe had the highest precipitation-gauge density at 2.4 gauges per 1,000 km².QUANTITATIVESupported
Replacing the Ni electrodes with Ni81Fe19 or replacing titanium with chromium strongly suppressed the thermally induced voltage in the experiment.COMPARATIVESupported
The experiment reported an orbital Nernst effect in titanium using Ni electrodes, detecting a thermally induced voltage dependent on magnetization direction and linear in the temperature gradient.OBSERVATIONALSupported
Under the study’s 2025–2100 SSP5-8.5 scenario combining projected precipitation and socioeconomic conditions, 32.1% of global land was classified as high priority for new gauges, versus 17.7% under SSP1-2.6.QUANTITATIVESupported
Using historical precipitation information from 1900–2022, the study classified approximately 25% of global land as high priority for siting new gauges.QUANTITATIVESupported
Only 13.4% of global land met the study’s WMO-recommended precipitation-gauge density during 1900–2022, falling to 1.9% when long-term-record stations alone were considered.QUANTITATIVESupported
The study compiled 221,483 accessible precipitation gauges with observations from 1900–2022, of which 139,901 (63.2%) remained active within the past 30 years.QUANTITATIVESupported
The LHCb analysis measured the Ω+cc mass as 3725.9 MeV/c² with separate statistical, systematic, lifetime, and external uncertainties.QUANTITATIVESupported
The LHCb analysis reported an 8.7-sigma global-significance structure in the Ω0cπ+ mass spectrum and identified it as the doubly charmed baryon Ω+cc.OBSERVATIONALSupported
In a corpus of 100 computational-biology papers, Paper2Agent successfully agentified 74 papers and produced 599 proposed tools, of which 593 passed automated validation.QUANTITATIVELeans supported
Under 2018 conditions, land-use disturbance corresponds to a potential European wetland soil-carbon storage difference of 0.8–4.9 Gt CO2-equivalent, not an annual emissions rate.QUANTITATIVELeans supported
The ETUCARE study reported that emotional-regulation skills mediated the relationships between intervention assignment and both procrastination and study engagement.INTERPRETIVESupported
In a randomized study of 436 participants, the ETUCARE online program increased study engagement and decreased academic procrastination over eight weeks compared with a control group.QUANTITATIVESupported
In the study’s 2018 European map, an estimated 27–33% of wetland area occurred in map-defined patches smaller than 25 hectares and 7–11% in patches smaller than 1 hectare.QUANTITATIVESupported
The study mapped six natural and seminatural open wetland types across large parts of Europe at 10-m resolution, estimating 413,504 ± 17,782 km2 with overall accuracy of 96.6 ± 0.3%.QUANTITATIVELeans supported
The northern New Mexico thinning-and-prescribed-burning treatments had less impact on beetle communities than clear-cutting or high-severity wildfire, according to the study.COMPARATIVELeans supported
The northern New Mexico restoration treatments were associated with 21 common beetle species increasing and 35 declining in the post-treatment sub-canopy environment.QUANTITATIVESupported
In a six-year northern New Mexico mixed-conifer case study, thinning followed by prescribed broadcast burning significantly changed surface-active beetle community composition.OBSERVATIONALSupported
The Foodsmart trial included 460 U.S. adults insured with Medicaid and experiencing persistently elevated blood sugar, with approximately two-thirds using insulin.QUANTITATIVESupported
After six months in the trial, 8.9% of the intervention group versus 3.4% of the usual-care group reached HbA1c below 7%.QUANTITATIVESupported
In a six-month randomized trial, the medically tailored-groceries plus telehealth intervention group had a larger HbA1c decrease than the usual-care group, 0.66 versus 0.44 percentage points.QUANTITATIVEUnresolved
The study trained GPN-Star for five model organisms beyond humans, demonstrating robustness and generalizability across those species.OBSERVATIONALSupported
In the study, GPN-Star achieved state-of-the-art performance across coding and non-coding human variant-effect prediction tasks.OBSERVATIONALSupported
GPN-Star is a phylogeny-aware genomic language model that uses whole-genome alignments and species trees to model evolutionary relationships.DEFINITIONALSupported
In the study, hindbrain activity was necessary for mesenteric-artery constriction and gut blood-flow reduction during hypoxia in zebrafish.CAUSALSupported
In larval zebrafish, WHOLISTIC revealed rhythmic travelling waves along the renal nephron and previously unknown muscle–organ interactions.OBSERVATIONALSupported
The study developed WHOLISTIC, a method for imaging second-timescale activity across the entire vertebrate body at cellular resolution.OBSERVATIONALSupported
In the study, water-derived hydroxyl-radical formation was identified as the rate-determining step in polyethylene oxidation, with a kH/kD isotope effect of 7.CAUSALSupported
The study achieved complete polyethylene conversion with nearly 69% selectivity to short-chain diacids and demonstrated scaling up to 300 g for mixed commercial plastics.QUANTITATIVESupported
The study reported a catalyst-free microdroplet-interface strategy using in situ hydroxyl radicals to oxidatively cleave diverse waste plastics into carboxylic acids under mild conditions.OBSERVATIONALSupported
The study used 19 astrometric positions of S301 that outlined an ellipse on the sky and yielded a consistent orbit.QUANTITATIVESupported
The fitted S301 orbit has eccentricity about 0.982–0.983 and a pericentre distance of approximately 136–142 Schwarzschild radii.QUANTITATIVESupported
The study's mechanistic investigations suggest that the deoxygenative functionalization begins with two-electron oxidative addition of a C–O bond to a low-valent chromium species, forming an organochromium intermediate.CAUSALLeans supported
The reported chromium-catalyzed strategy couples alcohols, ethers, and carbonyl compounds with electrophiles to produce organosilicon, organogermanium, organostannane, and organoboron compounds.OBSERVATIONALSupported
At the reported precision, the antihydrogen hyperfine measurement was sensitive to antiproton internal structure contributing about 40 ppm.QUANTITATIVESupported
Using microwave spectroscopy of roughly 24,000 anti-atoms, the study determined antihydrogen a1S/h as 1,420,404.8 ± 1.1(stat.) ± 5.6(sys.) kHz in a 1-T field.QUANTITATIVESupported
The study reported a 4-ppm measurement of antihydrogen’s ground-state hyperfine splitting, improving the prior state-of-the-art precision by two orders of magnitude.QUANTITATIVESupported
In the study, fractal dimension 2.41 and height range 7.96 cm produced oyster densities 35% higher than the maximum-dimension, 12-cm-height configuration.QUANTITATIVESupported
The study found that oyster settlement and survival were greatest at particular combinations of reef fractal dimension and height that minimized predation.CAUSALSupported
The study deployed 480 artificial oyster-habitat replicates spanning 16 geometries across three estuaries, with half caged against predation.QUANTITATIVESupported
At 370 km, all tested twin-field QKD links surpassed the PLOB repeaterless bound, with key-rate improvements ranging from 51.5% to 251.4%.COMPARATIVESupported