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Neuroscience

As of snapshot 27745 under ledger-default@0.3.0. Counts by assessment state, descriptive only: no topic is scored. 1 Contradicted3 Leans supported1 Not assessed22 Supported

ClaimTypeAssessment
In an adult mouse brain atlas, spatial distributions of 172 measured lipids formed 539 lipidome-defined territories called lipizones.OBSERVATIONALSupported
In pregnant female mice, increased SK3 activity in dorsal-raphe serotonin neurons reduced firing and promoted food-craving-like behavior; deleting SK3 reduced that behavior.CAUSALLeans supported
In the study's trisomy 21 samples, fibroblast chemokine expression was reduced while JAK–STAT signaling was enhanced.OBSERVATIONALSupported
The meningeal atlas data support a yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages described as primed for barrier immunity.INTERPRETIVESupported
The study constructed a paired single-nuclei RNA and chromatin-accessibility atlas of human meningeal development from 6 to 21 postconception weeks across cranial regions, integrated with spatial transcriptomics.OBSERVATIONALSupported
In the trial, closed-loop auditory stimulation enhanced stimulation-evoked slow-wave and fast-spindle activity while preserving sleep architecture and subjective sleep quality.COMPARATIVESupported
In the trial, closed-loop auditory stimulation significantly improved overnight word-pair consolidation, with Cohen’s dz = 0.42 and p = 0.04.QUANTITATIVESupported
A randomized, double-blind, placebo-controlled crossover trial tested one night of closed-loop auditory stimulation against sham stimulation in 37 patients with biomarker-confirmed early symptomatic Alzheimer disease.QUANTITATIVESupported
In the study, hindbrain activity was necessary for mesenteric-artery constriction and gut blood-flow reduction during hypoxia in zebrafish.CAUSALSupported
In larval zebrafish, WHOLISTIC revealed rhythmic travelling waves along the renal nephron and previously unknown muscle–organ interactions.OBSERVATIONALSupported
The study developed WHOLISTIC, a method for imaging second-timescale activity across the entire vertebrate body at cellular resolution.OBSERVATIONALSupported
The same re-analysis found only weak support for Zipf's law of abbreviation in the learned zebra-finch songs.QUANTITATIVESupported
Zebra finches tutored with shuffled-syllable songs produced learned songs exhibiting Menzerath's law and Zipf's rank-frequency law at levels similar to those in human language.COMPARATIVESupported
In the study, a neural classifier distinguished biological from linear virtual-conspecific motion with 72.6% classification accuracy during stimulus presentation and before the action.QUANTITATIVESupported
The study reported increased activity in optic-tectum and thalamic visual neurons when glassfish viewed escaping virtual conspecifics.OBSERVATIONALSupported
The study reported that Danionella cerebrum can mediate collective escape through an individual fish’s visual perception of escaping social partners.OBSERVATIONALSupported
In a 38-person online pilot randomized trial, adding an Emphasis Change attention-priority strategy to the Breakfast Game improved near-transfer multitasking and executive-control outcomes versus active control, but not distant-transfer mood or everyday cognitive-activity measures.QUANTITATIVELeans supported
The atlas identified cell-type-specific genes linked to Alzheimer’s disease, schizophrenia and other disorders that were not detected in bulk-tissue analyses.OBSERVATIONALSupported
A multi-ancestry human prefrontal-cortex atlas analyzed 5.6 million nuclei from 1,384 donors and identified genetic regulation for 14,258 genes across eight cell classes and 27 subclasses.QUANTITATIVESupported
In intracranial recordings from six human patients performing a gamified approach–avoidance task, medial orbitofrontal high-frequency activity increased before approach choices while lateral orbitofrontal activity decreased, revealing opposing decision-related signals before choice.OBSERVATIONALSupported
In the study's MPRA, Wnt stimulation increased activity for 32 elements, vehicle conditions increased activity for 7, and 12 variants showed significant condition-dependent allelic effects.QUANTITATIVESupported
In a massively parallel reporter assay of human neural progenitor cells, researchers tested 9,092 cortical-structure-associated variants and reported regulatory potential for 918 variants from 150 loci, representing 76% of loci studied; more than half showed allelic effects.QUANTITATIVESupported
The amygdala's scanning for danger gives humans a preponderance for focusing on bad news and treating the unfamiliar as dangerous.CAUSALLeans supported
Pachocki wrote that AI is grown more than designed, produced by running an optimization step billions of times and then studied the way neuroscientists study a brain.ATTRIBUTED_BELIEFSupported
Mind uploading will be solved within the next few years.FORECASTNot assessed
Most of the human brain is active almost all the time.QUANTITATIVESupported
Humans use only ten percent of their brains.QUANTITATIVEContradicted