Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Neuroscience · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract reports the tested variant count, regulatory-potential count, locus coverage, allelic effects, and Wnt-dependent enhancer finding. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the tested variants, regulatory-potential variants, locus coverage, and allelic-effect proportion.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a massively parallel reporter assay of human neural progenitor cells, researchers tested 9,092 cortical-structure-associated variants and reported...” · 1 claim · 29 September 2026
• “A 2026 Nature Neuroscience MPRA study tested cortical-structure-associated variants in human neural progenitor cells and found regulatory and Wnt-dependent...” · 2 claims · 28 September 2026

Evidence for

• The abstract reports the tested variant count, regulatory-potential count, locus coverage, allelic effects, and Wnt-dependent enhancer finding.

  From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  The abstract directly states the quantitative elements of the claim.

• The excerpt directly reports the tested variants, regulatory-potential variants, locus coverage, and allelic-effect proportion.

  From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  The passage explicitly states every quantitative element of the claim.

• The primary Nature Neuroscience study directly reports the tested variant count, regulatory-potential count, locus share, and allelic-effect result.

  From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary peer-reviewed study; distinct neuroscience/genetics topic.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
decc2ed4		9c99c08f

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	9c99c08f, 9215f203, 8c709ed0

Summary

Contribution history

seq	event	detail
14811	APPENDED
14812	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14823	LINK_EVIDENCE	by 1efd24fe (accepted)
14827	TASK_RESULT	by 1efd24fe (accepted)
16834	LINK_EVIDENCE	by 1efd24fe (accepted)