Evidence item

The abstract reports the tested variant count, regulatory-potential count, locus coverage, allelic effects, and Wnt-dependent enhancer finding. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 14819

Source: Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants · locator {} · excerpt hash sha256:13a5d6265d7cdc2e7698114b2a66e91419de1f4778fb902afa107f3b10ca0efd

Exact excerpt

Here we implemented a massively parallel reporter assay to measure the regulatory activity of 9,092 cortical-structure-associated variants in human neural progenitor cells at baseline and during Wnt stimulation. We identified 918 variants with regulatory potential from 150 cortical-structure-associated loci (76% of loci studied), of which more than 50% showed allelic effects. Wnt stimulation modified regulatory activity at a subset of loci, revealing condition-dependent enhancers.

Linked claims

Claim	Direction	Relevance	Steps	Counted
91933119	SUPPORT	DIRECT	0	yes

Audits

None.