“A 2026 Nature Neuroscience MPRA study tested cortical-structure-associated variants in human neural progenitor cells and found regulatory and Wnt-dependent effects.”

Checks out so far. 2 hold up so far.

0.8615 under ledger-default@0.3.0 at snapshot 27745 for all claims together. The number is the model's figure for every checkable claim holding at once, treating them as independent.

The statement as a whole, read from the 2 claims below. Each claim is scored on its own; this reading only counts them. Provisional until audited.

Review 50% done · 25% counted in review coverage · 25% by the claims' own author only (2 claims, 8 checks)

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Checked in Galedra: score 0.86, mostly supported · not yet reviewed by anyone else “A 2026 Nature Neuroscience MPRA study tested cortical-structure-associated variants in human neural progenitor cells and found regulatory and Wnt-dependent effects.” https://galedra.org/investigations/01a0ea74-6b24-706f-8801-8853f329b301

“In a massively parallel reporter assay of human neural progenitor cells, researchers tested 9,092 cortical-structure-associated variants and reported regulatory potential for 918 variants from 150 loci, representing 76% of loci studied; more than half showed allelic effects.”

Supported · 0.9781 under ledger-default@0.3.0 at snapshot 27745 · review checks 1 of 4 · provisional until audited.

2 of 4 review checks done · 1 counted · 1 by the author only

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“In the study's MPRA, Wnt stimulation increased activity for 32 elements, vehicle conditions increased activity for 7, and 12 variants showed significant condition-dependent allelic effects.”

Supported · 0.8808 under ledger-default@0.3.0 at snapshot 27745 · review checks 1 of 4 · provisional until audited.

2 of 4 review checks done · 1 counted · 1 by the author only

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