Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Neuroscience · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The results report 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent allelic variants. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent variants.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A 2026 Nature Neuroscience MPRA study tested cortical-structure-associated variants in human neural progenitor cells and found regulatory and Wnt-dependent...” · 2 claims · 28 September 2026

Evidence for

• The results report 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent allelic variants.

  From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  The results passage directly states each count and the significance threshold for condition-dependent variants.

• The excerpt directly reports the 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent variants.

  From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  The passage explicitly states each count and the FDR threshold for condition-dependent variants.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
d8c5f772		26cb961f

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	26cb961f, 81299243

Summary

Contribution history

seq	event	detail
14815	APPENDED
14816	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14825	LINK_EVIDENCE	by 1efd24fe (accepted)
14829	TASK_RESULT	by 1efd24fe (accepted)