As of snapshot 27745 under ledger-default@0.3.0. Counts by assessment state, descriptive only: no topic is scored.
1 Contradicted2 Insufficient evidence7 Leans supported86 Supported1 Unresolved
| Claim | Type | Assessment |
|---|
| In mice and pigs with traumatic brain injury, dynamic compressive tibial axial loading promoted motor and cognitive recovery, and osteocyte Piezo1 was required for the benefit in mice. | CAUSAL | Leans supported |
| Chemical dissociation of cytosolic myddosomes disrupted inflammatory activities of TLR-stimulated cells in vitro and in vivo. | CAUSAL | Leans supported |
| TRAM-dependent long-lasting myddosome activity determines hours-long NF-κB activation and secondary response gene expression in the studied TLR pathways. | CAUSAL | Leans supported |
| In macrophage models, TRAM regulates myddosome assembly by dissociating MyD88 from the TLR–TIRAP complex, enabling maturation of receptor-free cytosolic myddosomes and downstream signaling. | CAUSAL | Leans supported |
| The study's GWAS, cell-interaction analyses, and mouse validation indicate that peripheral nerves fine-tune maxilla shape during embryonic development. | CAUSAL | Leans supported |
| In the facial atlas, gene-expression associations with facial traits were strongest in early mesenchymal progenitor cells and became more region restricted over development. | OBSERVATIONAL | Supported |
| The study created a multimodal facial atlas across embryonic weeks 6–11 using single-cell transcriptomics, chromatin accessibility, and spatial transcriptomics, and characterized 56 cell states. | QUANTITATIVE | Supported |
| The STEP analysis found no significant treatment-by-metabolic-syndrome interaction for cardiovascular or safety outcomes, although hypotension was numerically more frequent with intensive treatment in the highest tertile. | QUANTITATIVE | Supported |
| Over a median 3.32-year follow-up, intensive systolic blood-pressure lowering was associated with lower primary cardiovascular-outcome risk than standard treatment across metabolic-syndrome tertiles; the largest reduction was in the middle tertile (HR 0.66, 95% CI 0.44–0.99). | QUANTITATIVE | Supported |
| A post hoc STEP-trial analysis included 8,231 participants with complete metabolic-syndrome severity data and used an age-, sex-, and ethnicity-specific scoring model. | OBSERVATIONAL | Supported |
| In the trial, closed-loop auditory stimulation enhanced stimulation-evoked slow-wave and fast-spindle activity while preserving sleep architecture and subjective sleep quality. | COMPARATIVE | Supported |
| In the trial, closed-loop auditory stimulation significantly improved overnight word-pair consolidation, with Cohen’s dz = 0.42 and p = 0.04. | QUANTITATIVE | Supported |
| A randomized, double-blind, placebo-controlled crossover trial tested one night of closed-loop auditory stimulation against sham stimulation in 37 patients with biomarker-confirmed early symptomatic Alzheimer disease. | QUANTITATIVE | Supported |
| The Foodsmart trial included 460 U.S. adults insured with Medicaid and experiencing persistently elevated blood sugar, with approximately two-thirds using insulin. | QUANTITATIVE | Supported |
| After six months in the trial, 8.9% of the intervention group versus 3.4% of the usual-care group reached HbA1c below 7%. | QUANTITATIVE | Supported |
| In a six-month randomized trial, the medically tailored-groceries plus telehealth intervention group had a larger HbA1c decrease than the usual-care group, 0.66 versus 0.44 percentage points. | QUANTITATIVE | Unresolved |
| The study tested selected synthetic promoters in primary human CD8-positive T cells and characterized an NR4A2-responsive subset in vitro and in tumor-infiltrating engineered T cells in a melanoma xenograft model. | OBSERVATIONAL | Supported |
| The study developed synthetic promoters responsive to seven transcription factors identified from T-cell activation programs, with a broad dynamic range of inducibility and basal expression. | OBSERVATIONAL | Supported |
| In the study's mouse model of lung protease hypersensitivity, memory of the initial event was stored in CCL11-expressing adventitial stromal cells; Ccl11 accessibility increased with papain exposure through IL-4/IL-13 and was blocked by interferon-γ. | OBSERVATIONAL | Supported |
| In the study's tumour models, abrupt stress increases rather than cumulative or peak stress magnitude determined epithelial–mesenchymal transition induction. | OBSERVATIONAL | Supported |
| The mechanoMR microparticle sensor study calibrated quantitative local tissue-stress measurements over a 0–15 kPa range and used the platform in tumour spheroids and mouse xenografts. | QUANTITATIVE | Supported |
| In aged-heart models, cardiac Vegfc overexpression or Il33 silencing restored lymphatic density and tissue homeostasis, identifying the VEGFC–IL-33 axis as a potential target for age-related cardiac dysfunction. | CAUSAL | Supported |
| Aging reduced cardiac lymphatic-vessel density in humans and mice, and experimentally reducing cardiac lymphatics in young mice recapitulated inflammation and impaired lymphatic integrity associated with cardiac aging. | CAUSAL | Supported |
| In streptomycin-treated mouse models of Salmonella Typhimurium infection, prophylactic colonization with engineered E. coli producing obligately lytic P22* phage reduced pathogen colonization and improved survival. | OBSERVATIONAL | Supported |
| In the study’s 14,644-patient RW2 cohort, EAGLE-Plus reduced false positives by 72.7% while maintaining comparable sensitivity. | QUANTITATIVE | Supported |
| In the study’s eight-center external CT test cohorts, EAGLE achieved 98.5% specificity, 90.0% cancer sensitivity and 52.5% precancerous-lesion sensitivity. | QUANTITATIVE | Supported |
| The EAGLE model was trained on 6,813 patients and validated across 12 centers in three countries involving 80,612 patients. | QUANTITATIVE | Supported |
| In experimental renal fibrosis, SRPX2 interacted with IRP1 and disrupted iron-regulatory signaling, and iron dextran supplementation alleviated UUO-induced renal fibrosis. | CAUSAL | Supported |
| SRPX2 expression was elevated in CKD patient kidney and serum samples and in experimental renal-fibrosis models, while global or tubular-epithelial deletion of Srpx2 attenuated kidney injury and fibrosis in mice. | CAUSAL | Supported |
| In mouse heart-attack models, blocking succinate dehydrogenase specifically in cardiomyocytes produced a transient proliferation increase that was insufficient by itself to improve heart function. | OBSERVATIONAL | Supported |
| In mouse heart-attack models, blocking succinate dehydrogenase in cardiac fibroblasts suppressed fibroblast activation and reduced scar formation, resulting in improved cardiac function. | OBSERVATIONAL | Supported |
| In the same skin-infection model, a later neutrophil-recruitment phase depended on Toll-like receptor and CXCL2 signaling, marking a transition to canonical pathogen-driven innate immunity. | CAUSAL | Supported |
| In a skin-infection model with pathogenic bacteria and fungi, microbial adhesion initiated an early PRR-independent neutrophil-recruitment phase by engaging Piezo1 and promoting leukotriene B4, interleukin-1α, and CXCL1 signaling. | CAUSAL | Supported |
| In a global analysis of 58,319 outbreak event records for 32 diseases, reporting declined by a median of 32% for each additional hour of travel time from a health facility. | QUANTITATIVE | Insufficient evidence |
| Sex-specific biological aging clocks predicted systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways in longitudinal survival analyses. | COMPARATIVE | Supported |
| A study developed 38 sex-specific biological aging clocks across 15 organ systems and found marked divergence between female and male clock outputs. | QUANTITATIVE | Supported |
| In a 15-cluster Singapore randomized trial, releases of irradiated Wolbachia wAlbB-infected male Aedes aegypti were associated with time-varying reductions in dengue incidence and an estimated 2,351 cases averted, though the effect attenuated during an inter-epidemic period. | QUANTITATIVE | Leans supported |
| In the randomized phase 3 LONESTAR trial of 166 immunotherapy-naive patients with metastatic non-small-cell lung cancer, adding local consolidative radiation or surgery after nivolumab plus ipilimumab did not significantly improve overall or progression-free survival. | QUANTITATIVE | Supported |
| In the NOHARM stepped-wedge cluster-randomized trial across six surgical centers, an EHR-based strategy promoting nondrug pain management reduced postoperative opioid exposure without worsening patient-reported pain interference, physical function, or reported safety outcomes. | QUANTITATIVE | Supported |
| In a double-blind pilot randomized trial of opioid-exposed newborns managed with Eat, Sleep, Console, high-calorie versus standard feeds showed no significant differences in weight loss, length of stay, or stool frequency, while breastfeeding at discharge was more frequent with high-calorie feeds. | QUANTITATIVE | Supported |
| In the Alliance A071801 randomized phase 3 trial of 242 patients with resected large brain metastases, three-to-five-session radiosurgery improved one-year surgical-bed control and median survival versus single-session radiosurgery without significant overall adverse-event differences. | QUANTITATIVE | Supported |
| In a 45-eye randomized trial of pseudophakic primary open-angle glaucoma, GATT produced greater 24-month intraocular-pressure and medication reductions and higher complete surgical success than BANG, with similar reoperation counts. | QUANTITATIVE | Insufficient evidence |
| A reported 13-year follow-up of a Danish randomized trial found no significant adolescent bone-mineral or fracture benefit from 2800 IU/day prenatal vitamin D compared with the standard 400 IU/day recommendation, despite earlier childhood gains. | QUANTITATIVE | Supported |
| A 2026 systematic review and meta-analysis reported that laboratory-confirmed enteric infection was associated with higher odds of childhood stunting, while grading the certainty of the evidence as very low. | QUANTITATIVE | Supported |
| In a murine MRSA infection model, IMP-2380 combined with ciprofloxacin produced a significant 100-fold reduction in bacterial burden, with three of five infections below the assay detection limit. | QUANTITATIVE | Supported |
| In a triple-masked randomized trial of 75 adults with subacromial pain syndrome, clinician-curated ChatGPT-4o and DeepSeek-R1 exercise programs added to standard physiotherapy did not improve six-week shoulder disability more than conventional programming, although an exploratory resting-pain difference favored DeepSeek-R1. | QUANTITATIVE | Supported |
| In a single-center randomized trial of 288 low-risk adults undergoing elective thyroid surgery, omitting face-mask ventilation caused no observed desaturation in either group, but formal non-inferiority was not established because the trial stopped early; exploratory gastric insufflation occurred only with ventilation. | QUANTITATIVE | Supported |
| In a randomized trial of 46 patients with lumbar disc herniation, both brochure-based and web telerehabilitation home exercise improved most outcomes; baseline-adjusted analyses favored telerehabilitation for activity-related pain and dynamic lumbar muscle performance, but not overall superiority. | QUANTITATIVE | Supported |
| In the phase 1 mRNA-1215 trial, antibody responses increased after the booster dose and remained elevated for at least one year. | QUANTITATIVE | Supported |
| In a phase 1, first-in-human trial of mRNA-1215 in 40 healthy adults, no serious adverse events occurred during the study. | QUANTITATIVE | Supported |
| In a stepped-wedge cluster-randomized trial across 15 German NICUs involving 1,627 very-low-birth-weight infants, structured lactation support combined with donor-milk banking increased exclusive mother’s own milk feeding at discharge by 11 percentage points without observed increases in major complications or length of stay. | QUANTITATIVE | Supported |
| In a nationwide prospective Swedish cohort of 181 children with acute leukemia, an integrated phenotyping, germline WGS panel, and tumor-sequencing strategy found cancer-predisposition diagnoses in 5.0%, with six of nine previously unrecognized and management changes in some cases. | QUANTITATIVE | Supported |
| In an Ethiopian phase II randomized trial of 183 adults with localized Leishmania aethiopica cutaneous leishmaniasis, single-session thermotherapy and weekly intralesional sodium stibogluconate had comparable intention-to-treat cure rates, while per-protocol final cure favored drug treatment; no serious adverse events occurred. | QUANTITATIVE | Supported |
| In a triple-blind multicenter randomized trial of 132 patients with persistent schizophrenia symptoms, low-intensity transcranial random-noise stimulation produced no significant improvement over sham at day 5 or on secondary outcomes, though it was well tolerated. | QUANTITATIVE | Supported |
| In a randomized controlled trial of 249 physicians in Indonesia, Kenya, and the Netherlands, GPT-4o access improved clinical-performance scores relative to control by 18 percentage points in Kenya, 10.7 in Indonesia, and 7.2 in the Netherlands under controlled conditions; harms were not assessed. | QUANTITATIVE | Supported |
| In the Proyecto Mamá randomized trial of 123 predominantly Puerto Rican women with overweight or obesity before pregnancy, a culturally tailored lifestyle intervention increased sports/exercise, household/caregiving, and light-intensity postpartum activity and doubled the odds of meeting ACOG activity guidelines, but did not improve combined moderate-to-vigorous activity or self-efficacy. | QUANTITATIVE | Supported |
| In an open-label pilot of 30 adults with Crohn’s disease, a single colonoscopic fecal microbiota transplant was associated with mucosal adherent-invasive E. coli decolonization in all 8 evaluable baseline-positive patients, with no FMT-related serious adverse events. | QUANTITATIVE | Supported |
| In a nationwide prospective Swedish cohort of 181 children with acute leukemia, a three-pronged phenotyping and sequencing strategy identified pathogenic germline alterations in 9 patients (5.0%); 8 of 9 received tailored surveillance and 4 of 9 had treatment modifications. | QUANTITATIVE | Supported |
| In a single-center single-arm phase-2 trial of 20 patients with advanced fumarate-hydratase-deficient renal-cell carcinoma, first-line tislelizumab plus lenvatinib produced a 95% objective response rate and 100% disease-control rate, while grade 3-or-higher treatment-related adverse events occurred in 45%. | QUANTITATIVE | Supported |
| In pooled test-negative case-control data from 2,243 Indian children hospitalized with acute gastroenteritis, three doses of ROTASIIL had 52% adjusted effectiveness against rotavirus-gastroenteritis hospitalization among children aged 3–23 months. | QUANTITATIVE | Supported |
| In a multicenter double-blind randomized trial of 1,152 women aged 35–42 at 13 Chinese fertility centers, non-invasive preimplantation genetic testing for aneuploidy did not significantly improve ongoing pregnancy rate versus morphology-based embryo selection. | QUANTITATIVE | Supported |
| In the SHIP HOPE cluster-randomized trial of 2,514 children in 10 Chinese primary schools, a comprehensive hygiene package did not significantly reduce one-year H. pylori prevalence or incidence, although it substantially improved H. pylori knowledge. | QUANTITATIVE | Supported |
| In a 12-month randomized HealthMPowerment trial among young Black and Latinx men who have sex with men and transgender women, the smartphone intervention did not improve routine HIV testing; apparent viral-suppression benefits were no longer significant after adjustment for baseline suppression, age and income. | QUANTITATIVE | Supported |
| In the Baby’s First Years randomized trial, low-income US mothers receiving US$333 per month rather than US$20 during their child’s first four years had four-year-old children with a 0.17-standard-deviation lower salivary DunedinPACE score, while maternal epigenetic indices showed no effect and child Epigenetic-g results were inconclusive. | QUANTITATIVE | Supported |
| In the three-month NeuroFit randomized trial of 52 healthy middle-aged UK adults, structured live-online exercise did not significantly improve pattern separation, but reduced depressive symptoms and changed an in-vitro proliferative-cell measure. | QUANTITATIVE | Supported |
| In the Southwest Ethiopia study, presumptive E. coli, Salmonella spp., Shigella spp., and Listeria spp. were observed at 42.1%, 29.2%, 18.6%, and 13.5%, respectively, across water, beef, and environmental samples, with significant variation by sample type and source. | QUANTITATIVE | Supported |
| A Southwest Ethiopia slaughter-to-plate study collected 349 samples from water, beef cuts, colon contents, and carcass swabs across a catchment river, two abattoirs, and 44 randomly selected beef retailers between February and May 2024. | QUANTITATIVE | Supported |
| In the phase II randomized RIO trial of 68 adult men living with HIV who interrupted ART, long-acting 3BNC117-LS and 10-1074-LS delayed viral rebound: median ART restart was 45.4 weeks with antibodies versus 4.6 weeks with placebo, and intact proviruses declined in the antibody arm. | QUANTITATIVE | Supported |
| The exploratory clinical-trial social-media comparison reported a Jaccard similarity coefficient of 0.159 between the Bluesky and Twitter/X discussion datasets. | QUANTITATIVE | Supported |
| In an exploratory comparison of clinical-trial discussions, Bluesky discourse was more cohesive and research-oriented with more specialized vocabulary, whereas Twitter/X discourse was more fragmented and event-driven. | COMPARATIVE | Supported |
| In a 711-participant randomized phase 2b trial of heart failure with preserved or mildly reduced ejection fraction, 48 weeks of mitiperstat did not improve symptoms, six-minute walk distance, or secondary endpoints versus placebo, although safety was generally similar. | QUANTITATIVE | Supported |
| In the U.S. oncology-trial analysis, ZIP codes in the lowest median-income tercile had significantly lower trial success rates than ZIP codes in the middle and highest income terciles; the lowest-versus-highest comparison reported p < 0.0001 and OR 1.13 [1.10–1.16]. | QUANTITATIVE | Supported |
| An analysis of 15,658 U.S. oncology clinical trials found that trial locations were skewed away from ZIP codes with lower median incomes. | QUANTITATIVE | Supported |
| In the NHS-Galleri trial's evaluable intervention participants across three annual rounds, the multi-cancer early-detection test had 99.50–99.60% specificity and 26.7–37.2% episode sensitivity for all cancers; these performance analyses were descriptive and the trial's primary late-stage-cancer endpoint was not met. | QUANTITATIVE | Supported |
| In a pragmatic cluster-randomized trial across 16 Kenyan primary-care facilities, LLM-assisted clinical officers did not significantly change 14-day treatment-failure rates versus control: 2.2% versus 2.0% (adjusted odds ratio 0.77, 95% CI 0.55–1.08, P=0.13). | QUANTITATIVE | Supported |
| In the PATHFINDER 2 study, among 32,007 performance-analyzable participants, the multi-cancer early-detection test had a 0.54% cancer detection rate, 60.3% positive predictive value, 99.2% negative predictive value, and 99.64% specificity. | QUANTITATIVE | Supported |
| In this real-world case-control study, prior metformin use was not associated with a statistically distinguishable difference in SARS-CoV-2 susceptibility (aOR 0.97, 95% CI 0.81–1.16). | QUANTITATIVE | Supported |
| In this real-world case-control study, prior metformin use was associated with lower odds of COVID-19 hospitalization and disease progression than use of no antidiabetic medication (hospitalization aOR 0.70, 95% CI 0.51–0.97; progression aOR 0.66, 95% CI 0.45–0.98). | QUANTITATIVE | Supported |
| In the study's MIRA-v2 evaluation, diagnostic behavioral consistency had AUC 0.860 for correctness discrimination and 0.875 under stress testing; a 0.90 threshold retained 49.4% of cases at 98.9% diagnostic accuracy. | QUANTITATIVE | Supported |
| In two MIMIC-IV-derived benchmarks, the evaluated on-premise clinical AI agent achieved 90.04% accuracy on a seven-disease task and 83.8% accuracy on a four-disease task. | QUANTITATIVE | Supported |
| In a retrospective metastatic prostate-cancer cohort, among cases classified as IMF6-high, androgen-receptor pathway inhibitor treatment was associated with lower treatment-failure risk than taxane treatment (HR 0.21, 95% CI 0.05–0.79, P = 0.021). | QUANTITATIVE | Supported |
| In a study of 959 primary prostate-cancer donors, eight integrated mutational footprints collectively explained the mutational processes in 85% of primary prostate-cancer genomes; four footprints present in 37% of primary tumours were associated with shorter time to metastasis. | QUANTITATIVE | Supported |
| In the same phase 1b/2 study, the regimen produced a 95% disease-control rate among the 40 analyzed participants. | QUANTITATIVE | Supported |
| In a South Korean phase 1b/2 study of 40 participants with previously untreated HER2-positive advanced biliary tract cancer, the trastuzumab-nivolumab-gemcitabine-cisplatin regimen produced a 55% objective response rate. | QUANTITATIVE | Supported |
| In that study, 6 of the 9 cancer-predisposition diagnoses were previously unrecognized; findings prompted tailored surveillance in 8 of 9 patients and treatment modifications in 4 of 9. | QUANTITATIVE | Supported |
| In a Swedish nationwide prospective population-based study of 181 children with acute leukemia, a three-pronged diagnostic strategy identified pathogenic germline alterations in 9 patients, an overall diagnostic yield of 5.0%. | QUANTITATIVE | Supported |
| In the testing cohort, PANXEON combined with CA19-9 detected stage I–II pancreatic ductal adenocarcinoma with 86.8% sensitivity, with false-positive rates of 3.2% in low-risk controls and 15.6% in high-risk controls. | QUANTITATIVE | Supported |
| Researchers applied prime assembly in primary human cells to targeted exon recoding, transgene integration, and megabase-scale rearrangements at therapeutically relevant loci. | OBSERVATIONAL | Supported |
| Prime assembly enables RNA-programmable, site-specific integration of medium-to-large DNA sequences in human cells without relying on nuclease-driven double-strand breaks or cell-cycle progression. | OBSERVATIONAL | Supported |
| In medical-record data, levetiracetam use was linked to longer survival for patients with diffuse midline gliomas but not for patients with hemispheric high-grade gliomas. | COMPARATIVE | Supported |
| In mice grafted with human diffuse midline gliomas, levetiracetam slowed malignant-cell growth. | OBSERVATIONAL | Supported |
| Mice vaccinated with the heat-stored MIT RNA-LNP formulation showed equivalent immune responses to mice receiving a comparable Moderna-like RNA-LNP formulation. | COMPARATIVE | Supported |
| An MIT-developed lipid nanoparticle formulation kept RNA vaccine particles stable at room temperature for up to one year or at 37°C (98°F) for two months. | QUANTITATIVE | Supported |
| Pairing Fountain Life's testing with healthy living changes improved members' brain age by 26 per cent. | QUANTITATIVE | Contradicted |
| Advanced testing found that one quarter of Fountain Life's members had advanced brain age. | QUANTITATIVE | Supported |
| Conservative estimates hold that 45 per cent of dementia cases are entirely preventable. | QUANTITATIVE | Supported |
| The Navier-Stokes equations govern fluid dynamics and underpin aircraft design, submarine design and modelling blood flow in artificial hearts. | OBSERVATIONAL | Leans supported |
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