Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract reports that sex-specific clocks predict systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways. weight 1.800000 evidence

Suppressed as dependent: The abstract reports sex- and organ-dependent prediction of systemic disease and all-cause mortality.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “Sex-specific biological aging clocks predicted systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways in longitudinal survival...” · 1 claim · 29 September 2026
• “A Nature Medicine study developed 38 sex-specific biological aging clocks across 15 organ systems and found divergent female and male aging signatures, with...” · 2 claims · 29 September 2026

Evidence for

• The abstract reports sex- and organ-dependent prediction of systemic disease and all-cause mortality.

  From Sex-specific biological aging clocks across organs and omics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The secondary report corroborates that sex-specific aging clocks were associated with mortality and sex-differentiated progression from mild cognitive impairment to Alzheimer’s disease.

  From Sex-specific biological clocks reveal how aging differs across the body in women and men Read 2026-09-29 Relevance STRONG Steps 1 Counted

  Secondary reporting of the same Nature Medicine study; corroborating article, not an independent aging cohort.

• The supplied abstract directly states that sex-specific clocks predicted systemic disease and all-cause mortality in sex- and organ-dependent ways.

  From Sex-specific biological aging clocks across organs and omics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt repeats the target claim's prediction result nearly verbatim.

• The abstract reports that sex-specific clocks predict systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways.

  From Sex-specific biological aging clocks across organs and omics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
9f43fc6e		f469b06e

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	b98b6cbd, f469b06e

Summary

Contribution history

seq	event	detail
19850	APPENDED
19851	ACCEPT	AUTOMATIC_AFTER_VALIDATION
19860	LINK_EVIDENCE	by 1efd24fe (accepted)
19874	LINK_EVIDENCE	by 1efd24fe (accepted)
22012	TASK_RESULT	by 1efd24fe (accepted)
24317	TASK_RESULT	by 1efd24fe (accepted)