Personal and public health, nutrition, vaccines.
As of snapshot 27745 under ledger-default@0.3.0. Counts by assessment state, descriptive only: no topic is scored.
4 Contradicted3 Insufficient evidence2 Leans supported1 Not assessed79 Supported1 Unresolved
| Claim | Type | Assessment |
|---|
| Over a median 3.32-year follow-up, intensive systolic blood-pressure lowering was associated with lower primary cardiovascular-outcome risk than standard treatment across metabolic-syndrome tertiles; the largest reduction was in the middle tertile (HR 0.66, 95% CI 0.44–0.99). | QUANTITATIVE | Supported |
| Among 205 adolescents at high risk for gaming disorder or unspecified internet use disorder, PROTECTtraining had lower 12-month symptom severity than PROTECTinfo, with between-group Cohen’s d −0.30 (95% CI −0.55 to −0.05). | QUANTITATIVE | Supported |
| At post-intervention, One Step Back participants reported lower depression scores by 5.54 points and higher well-being by 4.53 points than active controls. | QUANTITATIVE | Supported |
| The Foodsmart trial included 460 U.S. adults insured with Medicaid and experiencing persistently elevated blood sugar, with approximately two-thirds using insulin. | QUANTITATIVE | Supported |
| After six months in the trial, 8.9% of the intervention group versus 3.4% of the usual-care group reached HbA1c below 7%. | QUANTITATIVE | Supported |
| In a six-month randomized trial, the medically tailored-groceries plus telehealth intervention group had a larger HbA1c decrease than the usual-care group, 0.66 versus 0.44 percentage points. | QUANTITATIVE | Unresolved |
| In the study, observed outbreak reporting declined by a median of 32% for each additional hour of travel time from a health facility. | QUANTITATIVE | Supported |
| The study found outbreak risks were typically highest in mosaic landscapes where people and livestock coexist alongside forests and fragmented ecosystems, especially for several vector-borne diseases. | OBSERVATIONAL | Supported |
| The study consolidated 58,319 outbreak-event records covering 32 emerging infectious diseases to test social and environmental drivers of outbreak geography. | QUANTITATIVE | Supported |
| In mouse experiments, loss of GSDMD–TMEM106A protected against lethal sepsis but weakened antibacterial defence, while overexpression had opposite effects. | COMPARATIVE | Supported |
| In the study, inflammasome priming upregulated Gsdmd-Tmem106a and its protein localized to the plasma membrane. | OBSERVATIONAL | Supported |
| The study identified a protein-coding Gsdmd-Tmem106a chimeric mRNA in mouse macrophage immunity. | OBSERVATIONAL | Supported |
| In the study, deleting RANKL in lymphoid tissue organizer cells caused an almost complete absence of Thetis-cell subset TC I. | CAUSAL | Leans supported |
| In the study, PU.1 ablation in RORγt+ cells caused an almost complete absence of Thetis-cell subsets TC I–IV without impairing LTi cells. | COMPARATIVE | Supported |
| The study reported that mouse Thetis cells descend from the common lymphoid progenitor despite transcriptional similarity to conventional dendritic cells. | OBSERVATIONAL | Supported |
| The study's analysis of APN orthologues from 93 species found restricted EriCoV receptor tropism, primarily using hedgehog APN and, to a lesser extent, felid APN. | QUANTITATIVE | Supported |
| In mouse heart-attack models, blocking succinate dehydrogenase specifically in cardiomyocytes produced a transient proliferation increase that was insufficient by itself to improve heart function. | OBSERVATIONAL | Supported |
| In mouse heart-attack models, blocking succinate dehydrogenase in cardiac fibroblasts suppressed fibroblast activation and reduced scar formation, resulting in improved cardiac function. | OBSERVATIONAL | Supported |
| In a global analysis of 58,319 outbreak event records for 32 diseases, reporting declined by a median of 32% for each additional hour of travel time from a health facility. | QUANTITATIVE | Insufficient evidence |
| Sex-specific biological aging clocks predicted systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways in longitudinal survival analyses. | COMPARATIVE | Supported |
| A study developed 38 sex-specific biological aging clocks across 15 organ systems and found marked divergence between female and male clock outputs. | QUANTITATIVE | Supported |
| In a seven-year biomonitoring study of 1,003 Barred Owls in northwestern California, second-generation anticoagulant exposure among young owls fell from about 50% in 2019 to about 20% in 2024, while vitamin D3 rodenticide was detected in 18.5% overall and all rodenticides in up to 46%. | QUANTITATIVE | Supported |
| In a 15-cluster Singapore randomized trial, releases of irradiated Wolbachia wAlbB-infected male Aedes aegypti were associated with time-varying reductions in dengue incidence and an estimated 2,351 cases averted, though the effect attenuated during an inter-epidemic period. | QUANTITATIVE | Leans supported |
| The study analyzed 2,243 children aged 3–23 months hospitalized with acute gastroenteritis, of whom 638 were ELISA-positive for rotavirus. | QUANTITATIVE | Supported |
| In the study’s Indian hospital-based analysis, three ROTASIIL doses had estimated adjusted effectiveness of 56% against moderate rotavirus gastroenteritis and 54% against severe rotavirus gastroenteritis among children aged 3–23 months. | QUANTITATIVE | Supported |
| In the study’s Indian hospital-based analysis, three ROTASIIL doses had estimated adjusted effectiveness of 88% against rotavirus-gastroenteritis hospitalization among children aged 3–5 months. | QUANTITATIVE | Supported |
| In the randomized phase 3 LONESTAR trial of 166 immunotherapy-naive patients with metastatic non-small-cell lung cancer, adding local consolidative radiation or surgery after nivolumab plus ipilimumab did not significantly improve overall or progression-free survival. | QUANTITATIVE | Supported |
| In the NOHARM stepped-wedge cluster-randomized trial across six surgical centers, an EHR-based strategy promoting nondrug pain management reduced postoperative opioid exposure without worsening patient-reported pain interference, physical function, or reported safety outcomes. | QUANTITATIVE | Supported |
| A two-week pilot randomized trial of guided nature-based mindfulness versus unstructured outdoor walking found numerically favorable but non-significant differences in mental well-being and perceived stress, with no significant between-group difference in nature connectedness. | QUANTITATIVE | Supported |
| Across 357 Minnesota lakes, zebra mussel establishment was associated with increased mercury in harvestable-sized fish of four of six species, with species-specific increases of 6% to 21% and higher threshold exceedance risk in some fish. | QUANTITATIVE | Supported |
| In a double-blind pilot randomized trial of opioid-exposed newborns managed with Eat, Sleep, Console, high-calorie versus standard feeds showed no significant differences in weight loss, length of stay, or stool frequency, while breastfeeding at discharge was more frequent with high-calorie feeds. | QUANTITATIVE | Supported |
| In the Alliance A071801 randomized phase 3 trial of 242 patients with resected large brain metastases, three-to-five-session radiosurgery improved one-year surgical-bed control and median survival versus single-session radiosurgery without significant overall adverse-event differences. | QUANTITATIVE | Supported |
| In the 2026 HERBOT phase 1b/2 study of 40 participants with previously untreated HER2-positive advanced biliary tract cancer, median progression-free survival was 10.6 months with the trastuzumab-nivolumab-gemcitabine-cisplatin regimen. | QUANTITATIVE | Supported |
| In the 2026 HERBOT phase 1b/2 study of 40 participants with previously untreated HER2-positive advanced biliary tract cancer, the trastuzumab-nivolumab-gemcitabine-cisplatin regimen had a 95% disease-control rate. | QUANTITATIVE | Supported |
| The chickpea crossover study found evidence that oral bacterial strains reached the ileum after the meal, where their abundance was associated with local metabolites and PYY responses. | OBSERVATIONAL | Supported |
| In a randomized crossover study of ten participants, broken-cell chickpea meals produced early gastrointestinal glucose and maltose peaks associated with rapid GIP responses, whereas intact-cell meals elevated duodenal amino acids and ileal nutrients associated with enhanced GLP-1 and PYY responses. | COMPARATIVE | Supported |
| In a 45-eye randomized trial of pseudophakic primary open-angle glaucoma, GATT produced greater 24-month intraocular-pressure and medication reductions and higher complete surgical success than BANG, with similar reoperation counts. | QUANTITATIVE | Insufficient evidence |
| In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several mutations caused cross-resistance, while N6 and 1–18 largely retained activity. | QUANTITATIVE | Insufficient evidence |
| The atlas identified cell-type-specific genes linked to Alzheimer’s disease, schizophrenia and other disorders that were not detected in bulk-tissue analyses. | OBSERVATIONAL | Supported |
| A reported 13-year follow-up of a Danish randomized trial found no significant adolescent bone-mineral or fracture benefit from 2800 IU/day prenatal vitamin D compared with the standard 400 IU/day recommendation, despite earlier childhood gains. | QUANTITATIVE | Supported |
| A 2026 systematic review and meta-analysis reported that laboratory-confirmed enteric infection was associated with higher odds of childhood stunting, while grading the certainty of the evidence as very low. | QUANTITATIVE | Supported |
| In a murine MRSA infection model, IMP-2380 combined with ciprofloxacin produced a significant 100-fold reduction in bacterial burden, with three of five infections below the assay detection limit. | QUANTITATIVE | Supported |
| In a single-center randomized trial of 288 low-risk adults undergoing elective thyroid surgery, omitting face-mask ventilation caused no observed desaturation in either group, but formal non-inferiority was not established because the trial stopped early; exploratory gastric insufflation occurred only with ventilation. | QUANTITATIVE | Supported |
| In a randomized trial of 46 patients with lumbar disc herniation, both brochure-based and web telerehabilitation home exercise improved most outcomes; baseline-adjusted analyses favored telerehabilitation for activity-related pain and dynamic lumbar muscle performance, but not overall superiority. | QUANTITATIVE | Supported |
| In the phase 1 mRNA-1215 trial, antibody responses increased after the booster dose and remained elevated for at least one year. | QUANTITATIVE | Supported |
| In a phase 1, first-in-human trial of mRNA-1215 in 40 healthy adults, no serious adverse events occurred during the study. | QUANTITATIVE | Supported |
| In a stepped-wedge cluster-randomized trial across 15 German NICUs involving 1,627 very-low-birth-weight infants, structured lactation support combined with donor-milk banking increased exclusive mother’s own milk feeding at discharge by 11 percentage points without observed increases in major complications or length of stay. | QUANTITATIVE | Supported |
| An AI-guided Bayesian-optimization framework identified solid-state mRNA-lipid nanoparticle formulations that retained 100% bioactivity after more than two months at 37 °C, while inducing non-inferior antigen-specific responses in rodents and non-human primates versus fresh soluble vaccines. | QUANTITATIVE | Supported |
| In the same randomized evaluation, mean chart-review time was similar for human-plus-AI and human-alone prescreening (37.4 versus 37.8 minutes). | QUANTITATIVE | Supported |
| In a randomized evaluation of 355 oncology charts, human-plus-AI prescreening had higher chart-level accuracy than human-alone prescreening (76.1% versus 71.5%). | QUANTITATIVE | Supported |
| In an Ethiopian phase II randomized trial of 183 adults with localized Leishmania aethiopica cutaneous leishmaniasis, single-session thermotherapy and weekly intralesional sodium stibogluconate had comparable intention-to-treat cure rates, while per-protocol final cure favored drug treatment; no serious adverse events occurred. | QUANTITATIVE | Supported |
| In a triple-blind multicenter randomized trial of 132 patients with persistent schizophrenia symptoms, low-intensity transcranial random-noise stimulation produced no significant improvement over sham at day 5 or on secondary outcomes, though it was well tolerated. | QUANTITATIVE | Supported |
| In a cluster-randomized trial of 400 permanent-supportive-housing residents, a brief smoke-free-home intervention did not significantly increase adoption maintained for at least 90 days at six months, although it increased one-day smoke-free-home adoption and seven-day point-prevalence abstinence. | QUANTITATIVE | Supported |
| In the Proyecto Mamá randomized trial of 123 predominantly Puerto Rican women with overweight or obesity before pregnancy, a culturally tailored lifestyle intervention increased sports/exercise, household/caregiving, and light-intensity postpartum activity and doubled the odds of meeting ACOG activity guidelines, but did not improve combined moderate-to-vigorous activity or self-efficacy. | QUANTITATIVE | Supported |
| In an open-label pilot of 30 adults with Crohn’s disease, a single colonoscopic fecal microbiota transplant was associated with mucosal adherent-invasive E. coli decolonization in all 8 evaluable baseline-positive patients, with no FMT-related serious adverse events. | QUANTITATIVE | Supported |
| In a nationwide prospective Swedish cohort of 181 children with acute leukemia, a three-pronged phenotyping and sequencing strategy identified pathogenic germline alterations in 9 patients (5.0%); 8 of 9 received tailored surveillance and 4 of 9 had treatment modifications. | QUANTITATIVE | Supported |
| In a single-center single-arm phase-2 trial of 20 patients with advanced fumarate-hydratase-deficient renal-cell carcinoma, first-line tislelizumab plus lenvatinib produced a 95% objective response rate and 100% disease-control rate, while grade 3-or-higher treatment-related adverse events occurred in 45%. | QUANTITATIVE | Supported |
| In the Southwest Ethiopia study, presumptive E. coli, Salmonella spp., Shigella spp., and Listeria spp. were observed at 42.1%, 29.2%, 18.6%, and 13.5%, respectively, across water, beef, and environmental samples, with significant variation by sample type and source. | QUANTITATIVE | Supported |
| A Southwest Ethiopia slaughter-to-plate study collected 349 samples from water, beef cuts, colon contents, and carcass swabs across a catchment river, two abattoirs, and 44 randomly selected beef retailers between February and May 2024. | QUANTITATIVE | Supported |
| In the NHS-Galleri trial's evaluable intervention participants across three annual rounds, the multi-cancer early-detection test had 99.50–99.60% specificity and 26.7–37.2% episode sensitivity for all cancers; these performance analyses were descriptive and the trial's primary late-stage-cancer endpoint was not met. | QUANTITATIVE | Supported |
| In the PATHFINDER 2 study, among 32,007 performance-analyzable participants, the multi-cancer early-detection test had a 0.54% cancer detection rate, 60.3% positive predictive value, 99.2% negative predictive value, and 99.64% specificity. | QUANTITATIVE | Supported |
| In this real-world case-control study, prior metformin use was not associated with a statistically distinguishable difference in SARS-CoV-2 susceptibility (aOR 0.97, 95% CI 0.81–1.16). | QUANTITATIVE | Supported |
| In this real-world case-control study, prior metformin use was associated with lower odds of COVID-19 hospitalization and disease progression than use of no antidiabetic medication (hospitalization aOR 0.70, 95% CI 0.51–0.97; progression aOR 0.66, 95% CI 0.45–0.98). | QUANTITATIVE | Supported |
| In the reported study, the wearable optoacoustic device agreed with a reference cuff-based blood-pressure monitor, supporting its potential for continuous cuffless monitoring. | COMPARATIVE | Supported |
| In the reported study, the silicon-photonics optoacoustic detector measured high-contrast radial-artery signals at 100 Hz and captured features of the blood-pressure waveform. | OBSERVATIONAL | Supported |
| In the reported randomized crossover trial, N-acetylcysteine lowered ratings of perceived exertion and heart rate and increased Wingate average power in men. | COMPARATIVE | Supported |
| In the reported randomized crossover trial, seven-day N-acetylcysteine supplementation did not change 60-minute time-trial distance in trained men or women. | COMPARATIVE | Supported |
| The study reported that the CMIP6 inventory overestimated black-carbon radiative forcing by 45%. | QUANTITATIVE | Supported |
| A study using a localized black-carbon inventory and revised health-risk function estimated that over 540,000 premature deaths were attributable to black carbon in China in 2015. | QUANTITATIVE | Supported |
| In a retrospective metastatic prostate-cancer cohort, among cases classified as IMF6-high, androgen-receptor pathway inhibitor treatment was associated with lower treatment-failure risk than taxane treatment (HR 0.21, 95% CI 0.05–0.79, P = 0.021). | QUANTITATIVE | Supported |
| In Drosophila, genetic silencing of Lsp2 reduced early-adult ribosomal-protein abundance and translational activity while extending lifespan; restricting phenylalanine or tyrosine also reduced early-life Lsp2 and promoted longevity. | CAUSAL | Supported |
| In Drosophila, restricting protein intake during the larval stage promoted adult lifespan extension and durably downregulated Lsp2 expression in early adulthood. | CAUSAL | Supported |
| In the same phase 1b/2 study, the regimen produced a 95% disease-control rate among the 40 analyzed participants. | QUANTITATIVE | Supported |
| In a South Korean phase 1b/2 study of 40 participants with previously untreated HER2-positive advanced biliary tract cancer, the trastuzumab-nivolumab-gemcitabine-cisplatin regimen produced a 55% objective response rate. | QUANTITATIVE | Supported |
| In the testing cohort, PANXEON combined with CA19-9 detected stage I–II pancreatic ductal adenocarcinoma with 86.8% sensitivity, with false-positive rates of 3.2% in low-risk controls and 15.6% in high-risk controls. | QUANTITATIVE | Supported |
| In medical-record data, levetiracetam use was linked to longer survival for patients with diffuse midline gliomas but not for patients with hemispheric high-grade gliomas. | COMPARATIVE | Supported |
| In mice grafted with human diffuse midline gliomas, levetiracetam slowed malignant-cell growth. | OBSERVATIONAL | Supported |
| Mice vaccinated with the heat-stored MIT RNA-LNP formulation showed equivalent immune responses to mice receiving a comparable Moderna-like RNA-LNP formulation. | COMPARATIVE | Supported |
| An MIT-developed lipid nanoparticle formulation kept RNA vaccine particles stable at room temperature for up to one year or at 37°C (98°F) for two months. | QUANTITATIVE | Supported |
| WHO reported that more than 40% of planned insecticide-treated-net campaigns designed to reach 425 million people were delayed or at risk of derailment by early April 2025. | QUANTITATIVE | Supported |
| WHO reported that more than half of 64 surveyed malaria-endemic countries experienced moderate or severe disruptions to malaria services after funding cuts. | QUANTITATIVE | Supported |
| Trump provided no detail about the 50-state drug pricing deal he announced at the September 18, 2026 Oval Office event. | OBSERVATIONAL | Contradicted |
| At the same event Trump announced that all 50 states had signed on to a most-favored-nation program to lower prescription drug prices. | HISTORICAL | Supported |
| More than 150,000 people die on Earth each day. | QUANTITATIVE | Supported |
| Longevity should be treated as economic policy rather than a luxury, because a healthy 80-year-old is an economic contributor rather than a pension liability. | NORMATIVE | Not assessed |
| The global population over 65 is projected to grow from 852 million in 2025 to 2 billion by 2060, accounting for more than half of all population growth in that period. | QUANTITATIVE | Contradicted |
| Pairing Fountain Life's testing with healthy living changes improved members' brain age by 26 per cent. | QUANTITATIVE | Contradicted |
| Advanced testing found that one quarter of Fountain Life's members had advanced brain age. | QUANTITATIVE | Supported |
| Conservative estimates hold that 45 per cent of dementia cases are entirely preventable. | QUANTITATIVE | Supported |
| Drinking eight glasses of water every day is necessary for health. | CAUSAL | Contradicted |
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