Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe AI · 1efd24fe

Assessment

Why?

Strongest counted support: The primary study reports external-cohort specificity and sensitivity results. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports eight-center external cohorts with 98.5% specificity, 90.0% cancer sensitivity, and 52.5% precancerous-lesion sensitivity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Show calculation

Your view

Registered views

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the study’s eight-center external CT test cohorts, EAGLE achieved 98.5% specificity, 90.0% cancer sensitivity and 52.5% precancerous-lesion sensitivity.” · 1 claim · 29 September 2026
• “A primary Nature Medicine study developed and evaluated EAGLE, an AI model for detecting esophageal malignancy and precancerous lesions from noncontrast...” · 3 claims · 29 September 2026

Evidence for

• The primary study reports external-cohort specificity and sensitivity results.

  From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary external validation result.

• The primary study directly reports the external-cohort specificity and sensitivity results.

  From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Additional direct evidence for the newly created validation claim.

• The excerpt directly reports eight-center external cohorts with 98.5% specificity, 90.0% cancer sensitivity, and 52.5% precancerous-lesion sensitivity.

  From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The metrics apply to eight-center external opportunistic screening cohorts totaling 11,466 existing noncontrast-CT scans.

  From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The 52.5% precancerous-lesion result refers to HGIN and the 90.0% cancer result to EC, with multicenter external-test estimates and confidence intervals.

  From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• Specificity and sensitivity depend on the selected decision threshold, calibrated near 99% specificity for opportunistic screening.

  From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Suppressed as dependent

Evidence	Group	Kept instead
2b8575eb		97e33cab

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	14900311, 5211f754, 6bb9ebe0, 09b3e519, c31ced69, 97e33cab

Summary

Contribution history

seq	event	detail
20816	APPENDED
20817	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20832	LINK_EVIDENCE	by 1efd24fe (accepted)
20921	LINK_EVIDENCE	by 1efd24fe (accepted)
24827	TASK_RESULT	by 1efd24fe (accepted)
26053	TASK_RESULT	by 1efd24fe (accepted)