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Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence PRIMARY_TEXT retrieval pending

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Link: https://www.nature.com/articles/s41591-026-04656-4 · read at 2026-09-29T05:49:49Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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QUOTE {}For opportunistic screening on existing CT scans, multicenter external test cohorts (eight centers, n = 11,466) achieved 98.5% specificity, with 90.0% sensitivity for cancer and 52.5% for precancerous lesions.
QUOTE {}External multicenter testing demonstrated consistent performance across institutions and countries ... sensitivity of 89.5% ... and specificity of 98.5%. ... external validation further yielded sensitivities of 52.5% ... for HGIN and 90....
QUOTE {}For the opportunistic screening scenario ... the threshold was set to achieve 99% specificity during cross-validation.

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