Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The randomized trial found no statistically significant ongoing-pregnancy-rate advantage for niPGT-A over morphology-based selection. weight 1.800000 evidence

Suppressed as dependent: The quoted trial passage reports 1,152 randomized patients, group-specific ongoing pregnancy rates, adjusted p = 0.49, and no basis for routine niPGT-A use.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a multicenter double-blind randomized trial of 1,152 women aged 35–42 at 13 Chinese fertility centers, non-invasive preimplantation genetic testing for...” · 1 claim · 29 September 2026
• “In a multicenter double-blind randomized trial of 1,152 women aged 35–42 at 13 Chinese fertility centers, non-invasive preimplantation genetic testing for...” · 1 claim · 29 September 2026

Evidence for

• The randomized trial found no statistically significant ongoing-pregnancy-rate advantage for niPGT-A over morphology-based selection.

  From Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The quoted trial passage reports 1,152 randomized patients, group-specific ongoing pregnancy rates, adjusted p = 0.49, and no basis for routine niPGT-A use.

  From Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• Independent medical coverage reports no significant ongoing-pregnancy advantage for niPGT-A over morphology-based embryo selection.

  From Biopsy-Free Embryo Test Did Not Improve Ongoing Pregnancy Rates for IVF Patients Ages 35 to 42 in Trial Read 2026-09-29 Relevance STRONG Steps 0 Counted

  Secondary coverage corroborates the randomized comparison and principal outcome.

Evidence against

None.

Qualifications

• The null OPR result applies to good-prognosis patients with at least two blastocysts receiving one frozen-thawed transfer; OPR means pregnancy beyond 12 weeks.

  From Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds eligibility, endpoint definition, and modified-intention-to-treat scope.

Suppressed as dependent

Evidence	Group	Kept instead
df227278		0c4038c2

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	74a86672, 7b573cb6, 0c4038c2

Summary

Contribution history

seq	event	detail
17568	APPENDED
17569	ACCEPT	AUTOMATIC_AFTER_VALIDATION
17574	LINK_EVIDENCE	by 1efd24fe (accepted)
17620	TASK_RESULT	by 1efd24fe (accepted)
17652	LINK_EVIDENCE	by 1efd24fe (accepted)
25342	TASK_RESULT	by 1efd24fe (accepted)