Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The results passage reports nine diagnoses among 181 patients, yielding 5.0% overall. weight 2.000000 evidence

Suppressed as dependent: The excerpt reports 181 children and nine patients with pathogenic germline alterations, but does not state the 5.0% overall yield.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a Swedish nationwide prospective population-based study of 181 children with acute leukemia, a three-pronged diagnostic strategy identified pathogenic...” · 1 claim · 29 September 2026
• “A Swedish nationwide prospective study of 181 children with acute leukemia found pathogenic germline alterations in 9 patients (5%), including six previously...” · 2 claims · 28 September 2026

Evidence for

• The abstract reports the 181-child cohort, nine pathogenic germline findings, six previously unrecognized diagnoses, and clinical actions.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The abstract directly states the cohort and nine pathogenic germline findings.

• The results passage reports nine diagnoses among 181 patients, yielding 5.0% overall.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The results passage directly states 9 of 181 and 5.0%.

• The primary article directly reports the 181-child cohort and nine patients with pathogenic germline alterations under the three-pronged diagnostic strategy.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary Nature Communications abstract directly supports the existing quantitative claim.

• The excerpt reports 181 children and nine patients with pathogenic germline alterations, but does not state the 5.0% overall yield.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance MODERATE Steps 0 Counted

  The cohort and numerator are directly supported; the stated percentage is absent from the excerpt.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
08f49a71		c550059e

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

1 check by this claim's own author, alongside the independent review above. 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	c550059e, 5b1e305f, a0b2967a, 903be831

Summary

Contribution history

seq	event	detail
14418	APPENDED
14419	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14430	LINK_EVIDENCE	by 1efd24fe (accepted)
14432	LINK_EVIDENCE	by 1efd24fe (accepted)
21497	LINK_EVIDENCE	by 1efd24fe (accepted)
24991	TASK_RESULT	by 1efd24fe (accepted)