Claim

The study’s promoter results span HEK293 and Jurkat cell-line profiling, selected-promoter testing in primary human CD8-positive T cells, in-vitro NR4A2-subset characterization, and tumor-infiltrating engineered T cells in a melanoma xenograft model; these are experimental-system findings rather than clinical human evidence.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 25626

40 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 92 times: checked 0, looked up by assistants 0, viewed 92, shared 0. A count of attention, not evidence.

Topics

Not filed under any topic yet.

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 1 counted evidence item has no independence review; repeats of one origin may be counted as several coverage:63d658bd-f7d8-8228-bb5c-4a2c4c76c1ad

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.

Related: NARROWS outgoing: Supported

Why?

Strongest counted support: The primary text directly reports the stated cell-line profiling and selected-promoter experiments in primary CD8-positive T cells, in vitro, and melanoma xenograft tumor-infiltrating engineered T cells. weight 1.800000 evidence

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 1 source, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:6947421b3deed54365919cb694aedac46a93dc2d5264e3128acbad413af03076

Last changed at entry seq 25637; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
28674885 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Evidence for

The primary text directly reports the stated cell-line profiling and selected-promoter experiments in primary CD8-positive T cells, in vitro, and melanoma xenograft tumor-infiltrating engineered T cells.

From A modular synthetic promoter toolkit for programmable gene control in activated and chronically stimulated T cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Directly supports the experimental-system scope.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

None.

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
4c76c1ad	NARROWS	b249122a

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	28674885

Summary

Supported. The main support is: The primary text directly reports the stated cell-line profiling and selected-promoter experiments in primary CD8-positive T cells, in vitro, and melanoma xenograft tumor-infiltrating engineered T cells. dca3a32d

A search for evidence in the opposing direction found something; see the counted evidence. fd3caa55

Review checks: 1 of 4. coverage:63d658bd-f7d8-8228-bb5c-4a2c4c76c1ad

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
25626	APPENDED
25627	ACCEPT	AUTOMATIC_AFTER_VALIDATION
25636	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "63d658bd-f7d8-8228-bb5c-4a2c4c76c1ad",
  "links": [
    {
      "link": "1200b514-7e51-8033-8bda-17ef28674885",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "69e92374-0798-8225-83b7-73e9dca3a32d",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25637,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "1200b514-7e51-8033-8bda-17ef28674885"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 1
}