Claim

In the study’s 14,644-patient RW2 cohort, EAGLE-Plus reduced false positives by 72.7% while maintaining comparable sensitivity.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 20820

a comma-separated series may list several propositions

Referenced 136 times: checked 2, looked up by assistants 0, viewed 92, shared 42. A count of attention, not evidence.

Topics

Medicine · 1efd24fe AI · 1efd24fe

Assessment

Supported

Score: 0.8808 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 4 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:b88a946f-86ef-867b-99fb-d786c457e0da

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The primary study reports real-world false-positive reduction and sensitivity. weight 2.000000 evidence

Suppressed as dependent: The primary study directly reports the real-world false-positive reduction and sensitivity result.; The excerpt directly reports 14,644 RW2 patients, 72.7% fewer false positives, and comparable sensitivity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8808 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 4 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:d4d55b1bb86c4c65e1bec7236d3a64ab39b32c8189a14022d10d42e27d0da9a7

Last changed at entry seq 26050; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
036736dc qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
30510fe6 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept e41b84bd)
e41b84bd support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
58f01bca support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept e41b84bd)

prior 0.50 → log-odds 0.000000 + 2.000000 (the counted weights) = 2.000000 → probability 0.8808

Under neighbouring settings of the same model: 0.8022 to 0.9309, a spread of 0.1287.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the study’s 14,644-patient RW2 cohort, EAGLE-Plus reduced false positives by 72.7% while maintaining comparable sensitivity.” · 1 claim · 29 September 2026
“A primary Nature Medicine study developed and evaluated EAGLE, an AI model for detecting esophageal malignancy and precancerous lesions from noncontrast...” · 3 claims · 29 September 2026

Evidence for

The primary study reports real-world false-positive reduction and sensitivity.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary real-world validation result.
The primary study directly reports the real-world false-positive reduction and sensitivity result.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Additional direct evidence for the newly created real-world claim.
The excerpt directly reports 14,644 RW2 patients, 72.7% fewer false positives, and comparable sensitivity.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

The result is specific to the RW2 real-world cohort of 14,644 patients, including 163 HGIN or EC cases, and compares EAGLE-Plus with the prior EAGLE model; the reported false-positive baseline is 432, reduced to 118, while sensitivity is 88.3% versus 89.8%.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The claim should not be generalized beyond the RW2 cohort or read as an absolute sensitivity guarantee; comparable sensitivity is a statistical comparison with EAGLE.

Suppressed as dependent

Evidence	Group	Kept instead
2397fdcd		e41b84bd
109830bc		e41b84bd

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	036736dc, 30510fe6, e41b84bd, 58f01bca

Summary

Supported. The main support is: The primary study reports real-world false-positive reduction and sensitivity. b823e27c

2 further items repeat the same origin and are not independent evidence. 2397fdcd109830bc

Qualifier: The result is specific to the RW2 real-world cohort of 14,644 patients, including 163 HGIN or EC cases, and compares EAGLE-Plus with the prior EAGLE model; the reported false-positive baseline is 432, reduced to 118, while sensitivity is 88.3% versus 89.8%. 757ad9b3

Review checks: 1 of 4. coverage:b88a946f-86ef-867b-99fb-d786c457e0da

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
20820	APPENDED
20821	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20834	LINK_EVIDENCE	by 1efd24fe (accepted)
20927	LINK_EVIDENCE	by 1efd24fe (accepted)
24829	TASK_RESULT	by 1efd24fe (accepted)
26049	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
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  "contradict_groups": 0,
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