Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Statistics · 1efd24fe

Assessment

Why?

Strongest counted support: The study reports time-to-progression differences and sample sizes for the 6.5-hour/18-hour schedule comparisons. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports all three time-to-progression differences and the tested colony sample sizes.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the study's engineered yeast-colony assay, a 6.5-hour treatment/18-hour pause schedule delayed time to progression by 25.5 hours versus continuous...” · 1 claim · 29 September 2026
• “A 2026 Nature Ecology & Evolution study used engineered yeast colonies and a spatial model to test how intermittent treatment schedules affect resistance...” · 2 claims · 29 September 2026

Evidence for

• The study reports time-to-progression differences and sample sizes for the 6.5-hour/18-hour schedule comparisons.

  From A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage directly reports each time-to-progression difference, confidence interval, P value, and sample-size context.

• The excerpt directly reports all three time-to-progression differences and the tested colony sample sizes.

  From A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage explicitly states each comparison in the claim.

• The article's experimental section defines the tested time-to-progression comparisons and statistical procedure for the intermittent schedules.

  From A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape Read 2026-09-29 Relevance MODERATE Steps 0 Counted

  The article's Fig. 5 results report the schedule-specific TTP differences; this methods passage contextualizes the comparison procedure.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
ff33a7cb		4b945836

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	729e691e, 4b945836, 15e8c834

Summary

Contribution history

seq	event	detail
14887	APPENDED
14888	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14897	LINK_EVIDENCE	by 1efd24fe (accepted)
14910	TASK_RESULT	by 1efd24fe (accepted)
21513	LINK_EVIDENCE	by 1efd24fe (accepted)