Evidence item

A secondary scientific report corroborates elevated SRPX2 in CKD samples and attenuation of kidney injury and fibrosis after Srpx2 ablation in experimental models. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 20496

Source: 苏州大学团队发现肾纤维化新轴：SRPX2劫持IRP1致铁失调 · locator {} · excerpt hash sha256:54e1c0da27272a4aa76f6b440d3366b0013e669037ef72cc9132e2e9185c03f3

临床验证揭示，在各种肾脏病理类型的CKD患者的肾活检组织和血清样本中，SRPX2表达显著升高... Srpx2的整体和肾小管上皮细胞特异性消融足以减轻肾损伤和纤维化。