Evidence item

The primary atlas reports disease-linked cell-type-specific genes that bulk-tissue analyses did not detect. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 18656

Source: Single-nucleus atlas of cell-type specific genetic regulation in the human brain · locator {} · excerpt hash sha256:4926bc120390d8b04973f67dd4a732d128a2e0e17ad3d27f9433dbce7e02fe93

Colocalization of genetic variants associated with gene regulation and disease traits uncovers novel cell type-specific genes implicated in Alzheimer’s disease, schizophrenia and other disorders that were not detectable in bulk tissue analyses.