Evidence item

The primary abstract defines GPN-Star as a phylogeny-aware model using whole-genome alignments and species trees. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 22393

Source: Predicting genome-wide functional constraints with GPN-Star · locator {} · excerpt hash sha256:7aac7430adf3979f8c4856e6eeed96e623a093f40c1f4602dfc6e4e69fddac10

Here we introduce a genomic pretrained network with species tree and alignment representations (GPN-Star), which is a biologically grounded genomic language model featuring a phylogeny-aware architecture that leverages whole-genome alignments and species trees to model evolutionary relationships explicitly.