Evidence item

The study uses mouse and HK-2 cell models, while iron-dextran benefit is specifically reported for UUO-induced fibrosis. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25015

Source: Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease · locator {} · excerpt hash sha256:654d9de1a5e105d070b2f8c077927b51c6c39a29a3494f391e16c41468b5fdde

In two classic mouse renal fibrosis models of unilateral ureteral obstruction (UUO) and folic acid (FA)-induced nephropathy, as well as in TGF-β1-stimulated human renal tubular epithelial HK-2 cells, SRPX2 was significantly upregulated... Notably, therapeutic iron dextran supplementation alleviated UUO-induced renal fibrosis.