Evidence item

The human meningeal atlas directly supports a yolk-sac-origin interpretation using paired single-nuclei and spatial data sampled from 17 donors across 6–21 post-conception weeks. DATASET_RESULT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25727

Source: Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics · locator {} · excerpt hash sha256:4da7340d8a1d27aee2f1bd052f7ddb0d4c16fcc52c907d110719fcd5023fad9b

Exact excerpt

We constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks across cranial regions. By integrating spatial transcriptomics, we resolved cell types across meningeal layers. Within immune compartments, the data support a yolk sac origin for meningeal myeloid lineages, including perivascular macrophages primed for barrier immunity. Our data comprised tissues from 17 donors ranging from 6 to 21 postconception weeks, including trisomy 21 samples and male and female samples.

Linked claims

Claim	Direction	Relevance	Steps	Counted
aed2f1d4	SUPPORT	DIRECT	0	yes

Audits

None.