Evidence item

The study directly reports reduced Salmonella establishment and improved survival after prophylactic engineered-bacterium colonization in mice. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group 580316a6 · created seq 20895

Source: Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in mice · locator {} · excerpt hash sha256:3f3d187cf833ca95523a1cd935b3c381df7a0b3a9c76ce212b98f19f7b1e5e91

We show that prophylactic gut colonization with this lytic phage-producing lysogen of E. coli produces high levels of lytic phage before infection, inhibits the establishment of STm after infection and improves survival in mouse models of STm-induced colitis.