Evidence item

The 100-fold result was measured in young female C57BL/6 mice after a defined intraperitoneal inoculum, dosing schedule, and eight-hour endpoint. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25887

Source: Small-molecule inhibitors block NorA efflux by conformational trapping · locator {} · excerpt hash sha256:61e035e64f22db0d1fbb21a7edbfa8dd1a739accdb29d95514536cada37e6ee8

Female C57BL/6 mice (6–8 weeks) were infected intraperitoneally with 2.5 × 10^7 CFU S. aureus USA300 JE2; two hours post infection, mice received 30 mg/kg IMP-2380, ciprofloxacin, or both, and bacterial burden was assessed eight hours post infection.