Evidence item

The 5% yield combines six established leukemia-predisposition cases with three solid-tumor-predisposition findings not established as leukemia causes. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25356

Source: Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort · locator {} · excerpt hash sha256:9b44d068bc9af8aa890e9a897188c5af89620685d2119efc7a83b5b3a10a1db0

Exact excerpt

A cancer predisposition syndrome was identified in 9 of 181 patients, corresponding to an overall diagnostic yield of 5.0%. Six patients (6/181, 3.3%) carried genetic aberrations associated with established leukemia predisposition syndromes, whereas three patients (3/181, 1.7%) harbored heterozygous P/LP variants in ChiCaP genes associated with adult-onset predisposition to solid tumors.

Linked claims

Claim	Direction	Relevance	Steps	Counted
1fba5fff	QUALIFY	DIRECT	0	yes

Audits

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