Evidence item

The abstract reports Lsp2 silencing effects on translation, lifespan, and amino-acid restriction effects on Lsp2 and longevity. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 14849

Source: Lsp2 links early-life diet to adult translation and lifespan in Drosophila · locator {} · excerpt hash sha256:b3053649b205e9ed66ab993a1ef01206e458c9bd0cfeeeece9dc9504e1aaedb4

Exact excerpt

Genetic silencing of Lsp2 phenocopies ePR, attenuating ribosomal-protein abundance and translational activity in early adulthood, and extending lifespan. Restricting specific amino acids that are especially enriched in these storage proteins, such as phenylalanine and tyrosine, is sufficient to decrease the levels of early-life Lsp2 and promote longevity.

Linked claims

Claim	Direction	Relevance	Steps	Counted
265c876a	SUPPORT	DIRECT	0	yes

Audits

None.