Evidence item

Optogenetic hindbrain inhibition restored gut blood flow during hypoxia, and the authors conclude hindbrain activity is necessary for mesenteric-artery constriction. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 24428

Source: Imaging cellular activity across all organs reveals body-wide circuits · locator {} · excerpt hash sha256:5c113e2ebfb5aaa8b6ec258b50fca22f2ff49a9d00d4a9f045469f81884feb99

Exact excerpt

To more directly test this, we optogenetically inhibited the hindbrain during hypoxia while measuring blood flow. We found that inhibiting the hindbrain induced, within a few seconds, the return of blood flow to the gut. In spite of the hypoxic condition, near-normal blood flow was maintained for as long as the hindbrain was inhibited, with no corresponding effect observed when directing the stimulation light to a control location. Thus, hindbrain activity is necessary for the constriction of the mesenteric artery during hypoxia.

Linked claims

Claim	Direction	Relevance	Steps	Counted
8c6d9727	SUPPORT	DIRECT	0	yes

Audits

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