Evidence item

The primary article reports a later Pseudomonas phase requiring both CXCL1 and CXCL2, while MyD88 dependence does not uniquely identify TLR signaling. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25737

Source: Microbial adhesion promotes Piezo1 activation to initiate innate immunity · locator {} · excerpt hash sha256:a6633bbc9d84b3c5877577aa1acb6b30423b6d150c39df491f7867850dfc7352

At later stages of P. aeruginosa infection, however, both CXCL1 and CXCL2 were necessary for neutrophil recruitment to the infection site. It is noteworthy that CXCL1 production at very early time points after P. aeruginosa infection is dependent on IL-1α but becomes IL-1-independent and MyD88-dependent at later stages, similar to CXCL2 production.