Evidence item

An independent 2026 study of four liquid mRNA-LNP formulations found degradation at 5°C and complete transfection loss at 25°C within six months. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 13885

Source: Identifying Key Factors Affecting mRNA-Lipid Nanoparticles Drug Product Formulation Stability · locator {} · excerpt hash sha256:804d4e19a05a851f0224e4941e68c9951809bd7447087ead97ea28e9fc9766a5

Formulations stored at −80 °C and −20 °C retained acceptable stability, while storage at 5 °C caused aggregation, reduced in vivo expression, and mRNA degradation. Storage at 25 °C led to complete loss of transfection within six months.