Evidence item

The Nature Medicine study reports reduced proliferation and tumor burden with extended survival in DMG-bearing mice, but not in hemispheric high-grade glioma xenografts. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 13522

Source: Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma · locator {} · excerpt hash sha256:73a8da09d4f45f85841da3e24066231699430390318c96b3ab209ea0da7cd4b3

In preclinical models, levetiracetam reduces glioma proliferation and tumor burden, extending survival of mice bearing DMG orthotopic xenografts. These beneficial effects were not found in hemispheric high-grade glioma patient-derived orthotopic xenograft models.