Evidence item

The Nature study of 959 donors reports eight integrated mutational footprints explaining 85% of primary prostate-cancer genomes, with four footprints present in 37% of tumors linked to shorter time to metastasis. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 15907

Source: Integrated signatures define mutational processes in prostate cancer · locator {} · excerpt hash sha256:ba27d76463ab4407536ff7ad4d56f75705f3e85c77b291f11b0fd6fa7b23adf8

By integrating de novo extracted single-base substitution, insertion–deletion and copy-number signatures with six novel complex structural variant signatures, we identify eight integrated mutational footprints (IMFs) that collectively explain the mutational processes in 85% of primary prostate cancer genomes. Four IMFs, present in 37% of primary tumours, were significantly associated with shorter time to metastasis.